OMIA:001809-9615 : Leg morphology (leg width versus leg length) in Canis lupus familiaris (dog)

Categories: Limbs / fins / digit / tail phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Mapping: From a genome scan with 500 microsatellites genotyped in 330 Portuguese Water Dogs phenotyped for a range of measurable skeletal traits, Chase et al. (2002) identified QTL for four principal components of the skeletal traits, namely PC1 (Overall size of skeleton), PC2 (leg length versus width), PC3 (length of skull and limbs versus skull width and height) and PC4 (length of skull and limbs versus strength of limb and axial skeleton). Lark et al. (2006) reported mapping of the main QTL for PC2 to a 26Mb region on chromosome CFA12. Quignon et al. (2009) fine-mapped this QTL to a 500 kb region, very close to two collagen genes.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:001809-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2009 Quignon, P., Schoenebeck, J.J., Chase, K., Parker, H.G., Mosher, D.S., Johnson, G.S., Lark, K.G., Ostrander, E.A. :
Fine mapping a locus controlling leg morphology in the domestic dog. Cold Spring Harb Symp Quant Biol 74:327-33, 2009. Pubmed reference: 19717540. DOI: 10.1101/sqb.2009.74.009.
2006 Lark, K.G., Chase, K., Sutter, N.B. :
Genetic architecture of the dog: sexual size dimorphism and functional morphology. Trends Genet 22:537-44, 2006. Pubmed reference: 16934357. DOI: 10.1016/j.tig.2006.08.009.
2002 Chase, K., Carrier, D.R., Adler, F.R., Jarvik, T., Ostrander, E.A., Lorentzen, T.D., Lark, K.G. :
Genetic basis for systems of skeletal quantitative traits: principal component analysis of the canid skeleton. Proc Natl Acad Sci U S A 99:9930-5, 2002. Pubmed reference: 12114542. DOI: 10.1073/pnas.152333099.

Edit History

  • Created by Frank Nicholas on 21 May 2013
  • Changed by Frank Nicholas on 21 May 2013