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OMIA 001810-9615 : Beta blocker response in heart failure in Canis lupus familiaris

Mendelian trait/disorder: unknown

Considered a defect: no

Mapping: Lanfear et al. (2011) conducted a GWAS on left ventricular volume and ejection fraction after beta blocker treatment in 39 dogs with experimentally-induced heart failure, using the Illumina Canine SNP 20 SNP chip (comprising ~ 22,000 SNPs). SNPs on chromosomes CFA12 and 20 showed genome-wide significance for one of the traits.

Reference


2011 Lanfear, D.E., Yang, J.J., Mishra, S., Sabbah, H.N. :
Genome-wide approach to identify novel candidate genes for beta blocker response in heart failure using an experimental model. Discov Med 11:359-66, 2011. Pubmed reference: 21524389.

Edit History


  • Created by Frank Nicholas on 22 May 2013
  • Changed by Frank Nicholas on 05 Aug 2013