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OMIA 001811-9615 : Tail, curl in Canis lupus familiaris

Mendelian trait/disorder: unknown

Considered a defect: no

Mapping: Jones et al. (2008) conducted an across-breed GWAS on 2,801 dogs from 147 breeds, each genotyped for 674 equally spaced SNPs, plus an additional 862 SNPs located in regions of interest. The results highlighted regions on CFA1, 9, 25 and 38.

By conducting a mammoth proof-of-principle GWAS on "11 [breeds] with curly tails and 7 [breeds] with straight tails", with each dog being genotyped with Illumina CanineHD array (yielding 157,393 SNPs for analysis) developed for this study, Vaysse et al. (2011) highlighted a region between 96.26 and 96.96Mb on chromosome CFA1, which is flanked by the genes RCL1 and JAK2.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2011 Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Rosengren Pielberg, G., Sigurdsson, S., Fall, T., Seppälä, E.H., Hansen, M.S., Lawley, C.T., Karlsson, E.K. :
Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping. PLoS Genet 7:e1002316, 2011. Pubmed reference: 22022279. DOI: 10.1371/journal.pgen.1002316.
2008 Jones, P., Chase, K., Martin, A., Davern, P., Ostrander, EA., Lark, KG. :
Single-nucleotide-polymorphism-based association mapping of dog stereotypes. Genetics 179:1033-44, 2008. Pubmed reference: 18505865. DOI: 10.1534/genetics.108.087866.

Edit History


  • Created by Frank Nicholas on 22 May 2013
  • Changed by Frank Nicholas on 22 May 2013