OMIA 001811-9615 : Tail, curl in Canis lupus familiaris |
Mendelian trait/disorder:
unknown
Considered a defect:
yes
Mapping:
Jones et al. (2008) conducted an across-breed GWAS on 2,801 dogs from 147 breeds, each genotyped for 674 equally spaced SNPs, plus an additional 862 SNPs located in regions of interest. The results highlighted regions on CFA1, 9, 25 and 38.
By conducting a mammoth proof-of-principle GWAS on "11 [breeds] with curly tails and 7 [breeds] with straight tails", with each dog being genotyped with Illumina CanineHD array (yielding 157,393 SNPs for analysis) developed for this study, Vaysse et al. (2011) highlighted a region between 96.26 and 96.96Mb on chromosome CFA1, which is flanked by the genes RCL1 and JAK2.
Associated gene:| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| DVL2 | dishevelled segment polarity protein 2 | Canis lupus familiaris | 5 | NC_006587.3 (32201922..32194326) | DVL2 | Homologene, Ensembl, NCBI gene |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2011 | Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Rosengren Pielberg, G., Sigurdsson, S., Fall, T., Seppälä, E.H., Hansen, M.S., Lawley, C.T., Karlsson, E.K. : | |
| Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping. PLoS Genet 7:e1002316, 2011. Pubmed reference: 22022279. DOI: 10.1371/journal.pgen.1002316. | ||
| 2008 | Jones, P., Chase, K., Martin, A., Davern, P., Ostrander, EA., Lark, KG. : | |
| Single-nucleotide-polymorphism-based association mapping of dog stereotypes. Genetics 179:1033-44, 2008. Pubmed reference: 18505865. DOI: 10.1534/genetics.108.087866. |
Edit History
- Created by Frank Nicholas on 22 May 2013
- Changed by Frank Nicholas on 22 May 2013
- Changed by Frank Nicholas on 26 Mar 2019
- Changed by Frank Nicholas on 29 Mar 2019