OMIA 001852-9913 : Haplotype with homozygous deficiency NH2 in Bos taurus
This present OMIA entry is for NH2, which is located in chromosome BTA1, at 145.7–146.8Mb (UMD 3.1 genome assembly) (Fritz et al., 2013).
Mesbah-Uddin et al. (2019) "assume that NH2 was a false positive because of the lower power of detection in the analysis of Fritz et al. (2013) compared with that of the current study. Indeed, the present data set is 7-fold larger than the previous one, and the frequency of NH2 more than doubled in the population, which increased the probability of observing homozygotes."Prevalence: The NH2 haplotype occurs with a frequency of 3.8% in the 11,466 Normande adult cattle adult sampled by Fritz et al. (2013), but with only 29% of the expected frequency of homozygotes. Breed: Normande.
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2019||Mesbah-Uddin, M., Hoze, C., Michot, P., Barbat, A., Lefebvre, R., Boussaha, M., Sahana, G., Fritz, S., Boichard, D., Capitan, A., Mesbah-Uddin, M., Hoze, C., Michot, P., Barbat, A., Lefebvre, R., Boussaha, M., Sahana, G., Fritz, S., Boichard, D., Capitan, A. :|
|A missense mutation (p.Tyr452Cys) in the CAD gene compromises reproductive success in French Normande cattle. J Dairy Sci 102:6340-6356, 2019. Pubmed reference: 31056337. DOI: 10.3168/jds.2018-16100.|
|2013||Fritz, S., Capitan, A., Djari, A., Rodriguez, S.C., Barbat, A., Baur, A., Grohs, C., Weiss, B., Boussaha, M., Esquerré, D., Klopp, C., Rocha, D., Boichard, D. :|
|Detection of haplotypes associated with prenatal death in dairy cattle and identification of deleterious mutations in GART, SHBG and SLC37A2. PLoS One 8:e65550, 2013. Pubmed reference: 23762392. DOI: 10.1371/journal.pone.0065550.|
- Created by Frank Nicholas on 14 Jun 2013
- Changed by Frank Nicholas on 14 Jun 2013
- Changed by Frank Nicholas on 04 Jun 2019