OMIA:001866-9685 : Hypotrichosis, Don Sphynx in Felis catus (domestic cat) |
Categories: Integument (skin) phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal incomplete dominant
Considered a defect: yes
Key variant known: no
Species-specific name: Also known as Donskoy and Russian hairless
Inheritance: Zhigachev et al. (2000) reported autosomal incompletely dominant inheritance.
Molecular basis: In contrast to the situation with Canadian Sphynx cats, whose hairlessness is due to a mutation in KRT71 (see OMIA 001583-9685), Dierks et al. (2013) ruled out mutations in KRT71 as being causal for the hairlessness of Don Sphynx cats.
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Breed:
Don Sphynx (Cat) (VBO_0100085).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:001866-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2013 | Dierks, C., Lehner, S., Philipp, U., Distl, O. : |
| Elimination of keratin 71 as candidate for hairlessness in Don Sphynx cats. Anim Genet 44:607, 2013. Pubmed reference: 23914843. DOI: 10.1111/age.12068. | |
| 2000 | Zhigachev, A.I., Vladimirova, M.V., Katser, I.J. : |
| [Phenotypic and genotypic characteristics of Russian hairless cats] Russian Journal of Genetics 36:435-440, 2000. Pubmed reference: 10822817. |
Edit History
- Created by Frank Nicholas on 08 Aug 2013
- Changed by Frank Nicholas on 08 Aug 2013