OMIA:001866-9685 : Hypotrichosis, Don Sphynx in Felis catus (domestic cat)
Categories: Integument (skin) phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal incomplete dominant
Considered a defect: yes
Key variant known: no
Species-specific name: Also known as Donskoy and Russian hairless
Inheritance: Zhigachev et al. (2000) reported autosomal incompletely dominant inheritance.
Molecular basis: In contrast to the situation with Canadian Sphynx cats, whose hairlessness is due to a mutation in KRT71 (see OMIA 001583-9685), Dierks et al. (2013) ruled out mutations in KRT71 as being causal for the hairlessness of Don Sphynx cats.
Have human generated variants been created, e.g. through genetic engineering and gene editing
Don Sphynx (Cat) (VBO_0100085).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2013||Dierks, C., Lehner, S., Philipp, U., Distl, O. :|
|Elimination of keratin 71 as candidate for hairlessness in Don Sphynx cats. Anim Genet 44:607, 2013. Pubmed reference: 23914843. DOI: 10.1111/age.12068.|
|2000||Zhigachev, A.I., Vladimirova, M.V., Katser, I.J. :|
|[Phenotypic and genotypic characteristics of Russian hairless cats] Russian Journal of Genetics 36:435-440, 2000. Pubmed reference: 10822817.|
- Created by Frank Nicholas on 08 Aug 2013
- Changed by Frank Nicholas on 08 Aug 2013