OMIA:001877-9615 : Pyoderma in Canis lupus familiaris (dog)
Categories: Integument (skin) phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: previously called 'Pyoderma, German Shepherd'
Species-specific name: German Shepherd dog pyoderma
Inheritance: Wisselink et al. (1989) presented pedigree data and claimed autosomal recessive inheritance, but did not actually conduct a segregation analysis.
Rosser (2006): "Although dogs with GSP may have clinically similar presentations, the underlying causes of the disease process can be multifactorial in etiology. ... [P]urebred German Shepherd Dogs are predisposed to the development of this disease, but it is important to note that a similar condition may occur in German Shepherd crossbred dogs and other herding breeds of dogs ..."
Have human generated variants been created, e.g. through genetic engineering and gene editing
Clinical features: Rosser (2006): "The most common lesion initially observed in cases of GSP is clinically similar to that of a “hot spot” and is usually first noticed in the lumbosacral region, lateral hip, or lateral thigh region ... . As the disease progresses, several additional lesions may be observed, including areas of posttraumatic alopecia, hyperpigmentation, papules, pustules, hemorrhagic bullae, ulcers, crusts, and draining tracts (usually with a hemopurulent discharge) with surrounding friable tissue. The disease ultimately takes on the appearance of chronic deep pyoderma or cellulitis, and there is frequently an associated regional lymphadenopathy. Less commonly observed clinical signs may include a purulent otitis externa, perianal fistulas, focal metatarsal fistulas (sterile pedal panniculitis), and fever with signs of systemic illness [Denerolle et al., 1998; Rosser 1997; Ihrke & DeManuelle, 1999]."
German Shepherd Dog (Dog) (VBO_0200577).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2023||Santoro, D. :|
|Topical therapy for canine pyoderma: what is new? J Am Vet Med Assoc 261:S140-S148, 2023. Pubmed reference: 36921021. DOI: 10.2460/javma.23.01.0001.|
|2018||Loeffler, A., Lloyd, D.H. :|
|What has changed in canine pyoderma? A narrative review. Vet J 235:73-82, 2018. Pubmed reference: 29704943. DOI: 10.1016/j.tvjl.2018.04.002.|
|2014||Zur, G., Soback, S., Weiss, Y., Perry, E., Lavy, E., Britzi, M. :|
|Azithromycin pharmacokinetics in the serum and its distribution to the skin in healthy dogs and dogs with pyoderma. Vet J , 2014. Pubmed reference: 24472431. DOI: 10.1016/j.tvjl.2013.12.022.|
|2006||Rosser, E.J. :|
|German Shepherd Dog pyoderma. Vet Clin North Am Small Anim Pract 36:203-11, viii, 2006. Pubmed reference: 16364785. DOI: 10.1016/j.cvsm.2005.09.008.|
|2004||Bassett, R.J., Burton, G.G., Robson, D.C. :|
|Antibiotic responsive ulcerative dermatoses in German Shepherd Dogs with mucocutaneous pyoderma. Aust Vet J 82:485-9, 2004. Pubmed reference: 15359964.|
|1999||Ihrke, P. J., DeManuelle, T. C. :|
|German shepherd dog pyoderma: an overview and antimicrobial management. Compendium on Continuing Education for the Practicing Veterinarian 21:44-49, 1999.|
|1998||Cerundolo, R., De Caprariis, D., Manna, L., Gravino, A.E. :|
|Recurrent deep pyoderma in German Shepherd dogs with underlying ehrlichioses and hypergammaglobulinaemia. Vet Dermatol 9:135-142, 1998. Pubmed reference: 34645013. DOI: 10.1046/j.1365-3164.1998.00102.x.|
|Denerolle, P., Bourdoiseau, G., Magnol, J., Ulpat, C., Chabanne, L. :|
|German shepherd dog pyoderma: A prospective study of 23 cases. Veterinary Dermatology 9:243-248, 1998. DOI: 10.1046/j.1365-3164.1998.00105.x.|
|1997||Rosser, E.J. :|
|German shepherd dog pyoderma: a prospective study of 12 dogs. J Am Anim Hosp Assoc 33:355-63, 1997. Pubmed reference: 9204474.|
|Shearer, D.H., Day, M.J. :|
|Aspects of the humoral immune response to Staphylococcus intermedius in dogs with superficial pyoderma, deep pyoderma and anal furunculosis. Vet Immunol Immunopathol 58:107-20, 1997. Pubmed reference: 9336879.|
|Toman, M., Svoboda, M., Rybnícek, J., Krejcí, J., Faldyna, M., Bárta, O. :|
|Immunosuppression in dogs with pyoderma and/or demodicosis. Vet Med (Praha) 42:299-306, 1997. Pubmed reference: 9416010.|
|1996||Koch, H.J., Peters, S. :|
|Antimicrobial therapy in German Shepherd dog pyoderma (GSP). An open clinical study. Vet Dermatol 7:177-181, 1996. Pubmed reference: 34644986. DOI: 10.1111/j.1365-3164.1996.tb00243.x.|
|1995||Chabanne, L., Marchal, T., Denerolle, P., Magnol, J.P., Fournel, C., Monier, J.C., Rigal, D. :|
|Lymphocyte subset abnormalities in German shepherd dog pyoderma (GSP). Vet Immunol Immunopathol 49:189-98, 1995. Pubmed reference: 8746694.|
|Day, M.J., Mazza, G. :|
|Tissue immunoglobulin G subclasses observed in immune-mediated dermatopathy, deep pyoderma and hypersensitivity dermatitis in dogs. Res Vet Sci 58:82-9, 1995. Pubmed reference: 7709067.|
|1994||Day, M.J. :|
|An immunopathological study of deep pyoderma in the dog. Res Vet Sci 56:18-23, 1994. Pubmed reference: 8146448.|
|1990||Wisselink, M.A., Koeman, J.P., van den Ingh, T.S., Willemse, A. :|
|Investigations on the role of staphylococci in the pathogenesis of German shepherd dog pyoderma (GSP). Vet Q 12:29-34, 1990. Pubmed reference: 2321349. DOI: 10.1080/01652176.1990.9694238.|
|Wisselink, M.A., Koeman, J.P., van den Ingh, T.S., Willemse, A. :|
|Investigations on the role of flea antigen in the pathogenesis of German shepherd dog pyoderma (GSP). Vet Q 12:21-8, 1990. Pubmed reference: 2321348. DOI: 10.1080/01652176.1990.9694237.|
|1989||Wisselink, M.A., Bouw, J., der Weduwen, S.A., Willemse, A. :|
|German shepherd dog pyoderma: a genetic disorder. Vet Q 11:161-4, 1989. Pubmed reference: 2781707. DOI: 10.1080/01652176.1989.9694215.|
|1988||Wisselink, M.A., Bernadina, W.E., Willemse, A., Noordzij, A. :|
|Immunologic aspects of German shepherd dog pyoderma (GSP). Vet Immunol Immunopathol 19:67-77, 1988. Pubmed reference: 3176335.|
- Created by Frank Nicholas on 05 Sep 2013
- Changed by Frank Nicholas on 05 Sep 2013
- Changed by Imke Tammen2 on 21 May 2022