OMIA:001882-9615 : Attention deficit hyperactivity disorder in Canis lupus familiaris (dog)

Categories: Behaviour / neurological phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 143465 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific name: Activity, impulsivity and inattention

Species-specific symbol: ADHD

Markers: Hejjas et al. (2007; Mammalian Genome) reported tentative findings of associations between polymorphisms in canine DRD4, DBH, and DAT genes and attention deficit in Belgian Tervuerens. Hejjas et al. (2007; Animal Genetics) provided stronger evidence for association between the DRD4 gene and the "activity-impulsivity dimension of the dog-ADHD Rating Scale" in 'police' German Shepherd dogs. Kubinyi et al. (2012) reported similar associations with polymorphism at the TH gene in German Shepherd dogs. Wan et al. (2013) found similar associations for DRD4 and TH in Siberian Huskies.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:001882-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2013 Wan, M., Hejjas, K., Ronai, Z., Elek, Z., Sasvari-Szekely, M., Champagne, F.A., Miklósi, A., Kubinyi, E. :
DRD4 and TH gene polymorphisms are associated with activity, impulsivity and inattention in Siberian Husky dogs. Anim Genet , 2013. Pubmed reference: 23713429. DOI: 10.1111/age.12058.
2012 Kubinyi, E., Vas, J., Hejjas, K., Ronai, Z., Brúder, I., Turcsán, B., Sasvari-Szekely, M., Miklósi, A. :
Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs. PLoS One 7:e30271, 2012. Pubmed reference: 22272320. DOI: 10.1371/journal.pone.0030271.
2009 Hejjas, K., Kubinyi, E., Ronai, Z., Szekely, A., Vas, J., Miklósi, A., Sasvari-Szekely, M., Kereszturi, E. :
Molecular and behavioral analysis of the intron 2 repeat polymorphism in the canine dopamine D4 receptor gene. Genes Brain Behav 8:330-6, 2009. Pubmed reference: 19382953. DOI: 10.1111/j.1601-183X.2008.00475.x.
2007 Hejjas, K., Vas, J., Topal, J., Szantai, E., Ronai, Z., Szekely, A., Kubinyi, E., Horvath, Z., Sasvari-Szekely, M., Miklosi, A. :
Association of polymorphisms in the dopamine D4 receptor gene and the activity-impulsivity endophenotype in dogs. Anim Genet 38:629-33, 2007. Pubmed reference: 17986156. DOI: 10.1111/j.1365-2052.2007.01657.x.
Hejjas, K., Vas, J., Kubinyi, E., Sasvari-Szekely, M., Miklosi, A., Ronai, Z. :
Novel repeat polymorphisms of the dopaminergic neurotransmitter genes among dogs and wolves. Mamm Genome 18:871-9, 2007. Pubmed reference: 18049838. DOI: 10.1007/s00335-007-9070-0.

Edit History

  • Created by Frank Nicholas on 18 Sep 2013
  • Changed by Frank Nicholas on 18 Sep 2013