OMIA:001959-9913 : Haplotype with homozygous deficiency FH3 in Bos taurus (taurine cattle)
Categories: Mortality / aging (incl. embryonic lethal)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal recessive, semi-lethal
Considered a defect: yes
Key variant known: no
Mapping: Chromosome BTA10: 26,929,817-35,479,280 (UMD3.1 genome assembly) (Pausch et al., 2015)
Have human generated variants been created, e.g. through genetic engineering and gene editing
Simmental (Cattle) (VBO_0000380).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
|2015||Pausch, H., Schwarzenbacher, H., Burgstaller, J., Flisikowski, K., Wurmser, C., Jansen, S., Jung, S., Schnieke, A., Wittek, T., Fries, R. :|
|Homozygous haplotype deficiency reveals deleterious mutations compromising reproductive and rearing success in cattle. BMC Genomics 16:312, 2015. Pubmed reference: 25927203. DOI: 10.1186/s12864-015-1483-7.|
- Created by Frank Nicholas on 28 Apr 2015
- Changed by Frank Nicholas on 28 Apr 2015