OMIA 001998-9986 : Dwarfism, Dahlem in Oryctolagus cuniculus

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Key variant known: no

Species-specific symbol: da

History: As summarised by Robinson (1958), "A third form of dwarfism has been reported by NACHTSHEIM (1937a) and by SCHNECKE (1941) which differ in several details from" Achondroplasia-1 (OMIA 001996-9986) and achondroplasia-2 (001997-9986).

Clinical features: As summarised by Robinson (1958): "These dwarfs are a little more viable, many surviving to the age of 3 weeks, although some die soon after birth. The gene, da, is not fully recessive and homozygous dwarfs, dada, are approximately half the normal weight and their subsequent growth is very tardy. The head is abnormally short and the lower incisors may lie in front of the upper instead of behind; consequently the teeth may be excessively long. The forehead appears swollen and the eyeballs 'protrude (exophthalmus). The heterozygote is smaller than the homozygous normal somewhat similarly to the other dwarf types."

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
1958 Robinson, R. :
Genetic studies of the rabbit. Bibliographia Genetica 17:229–558, 1958.
1941 Schnecke, C. :
Zwergwuch beim Kaninchen und seine Vererbung Z. Menschl. Vererbgs. Konstl 25:425-457, 1941.
1937 Nachtsheim, H. :
Erbpathologie des Kaninchen Erbarzt (Leipzig) 4:25-30, 1937.

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  • Created by Frank Nicholas on 28 Apr 2016
  • Changed by Frank Nicholas on 28 Apr 2016