OMIA:001998-9986 : Dwarfism, Dahlem in Oryctolagus cuniculus
Categories: Skeleton phene (incl. short stature & teeth)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal recessive
Considered a defect: yes
Key variant known: no
Species-specific symbol: da
History: As summarised by Robinson (1958), "A third form of dwarfism has been reported by NACHTSHEIM (1937a) and by SCHNECKE (1941) which differ in several details from" Achondroplasia-1 (OMIA 001996-9986) and achondroplasia-2 (001997-9986).
Clinical features: As summarised by Robinson (1958): "These dwarfs are a little more viable, many surviving to the age of 3 weeks, although some die soon after birth. The gene, da, is not fully recessive and homozygous dwarfs, dada, are approximately half the normal weight and their subsequent growth is very tardy. The head is abnormally short and the lower incisors may lie in front of the upper instead of behind; consequently the teeth may be excessively long. The forehead appears swollen and the eyeballs 'protrude (exophthalmus). The heterozygote is smaller than the homozygous normal somewhat similarly to the other dwarf types."
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|1958||Robinson, R. :|
|Genetic studies of the rabbit. Bibliographia Genetica 17:229–558, 1958.|
|1941||Schnecke, C. :|
|Zwergwuch beim Kaninchen und seine Vererbung Z. Menschl. Vererbgs. Konstl 25:425-457, 1941.|
|1937||Nachtsheim, H. :|
|Erbpathologie des Kaninchen Erbarzt (Leipzig) 4:25-30, 1937.|
- Changed by Frank Nicholas on 28 Apr 2016
- Created by Frank Nicholas on 28 Apr 2016