OMIA 002007-9685 : Agenesis, renal in Felis catus

In other species: rabbit , dog

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 617805 (trait) , 601076 (trait) , 277000 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Bilateral renal agenesis leads to perinatal death. Animals with unilateral agenesis are often asymptomatic.

Species-specific name: Unilateral renal agenesis, segmental uterine aplasia (or uterus unicornis) with ipsilateral renal agenesis

Species-specific description: Renal agenesis of one kidney may lead to compensatory hypertrophy of the contralateral kidney. Due to this compensatory mechanism, the patient may be asymptomatic (Greco, 2001).

Segmental uterine aplasia (uterus unicornis) with ipsilateral renal agenesis occurs as a result of abnormal differentiation of the Mullerian duct development (Chang et al., 2008). As a result, unilateral renal agenesis and ovarian duct agenesis occurs with both ovaries normal and present.

(Compiled by Rachel Natsume 13/9/2021)

Clinical features: Often incidental finding during ovariohysterectomy. Likely asymptomatic with compensatory hypertrophy of contralateral kidney (Greco, 2001).

(Compiled by Rachel Natsume 13/9/2021)

Pathology: Renal agenesis can be confirmed with abdominal ultrasonography. Histopathology of segmental uterine aplasia "showed that the associated uterine tissue contained smooth muscle, collagen, and blood vessels but lacked any normal uterine tissue. In contrast to these abnormalities, the right ovarian structure was normal, as were the isthmus and infundibulum.” (Dykeman 2020)

(Compiled by Rachel Natsume 13/9/2021)

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 Dykeman, D. :
Segmental uterine aplasia and ipsilateral renal agenesis in a ragdoll cat. Can Vet J 61:424-426, 2020. Pubmed reference: 32255831.
2017 Brookshire, W.C., Shivley, J., Woodruff, K., Cooley, J. :
Uterus unicornis and pregnancy in two feline littermates. JFMS Open Rep 3:2055116917743614, 2017. Pubmed reference: 29270306. DOI: 10.1177/2055116917743614.
2013 Carvallo, F.R., Wartluft, A.N., Melivilu, R.M. :
Unilateral uterine segmentary aplasia, papillary endometrial hyperplasia and ipsilateral renal agenesis in a cat. J Feline Med Surg 15:349-52, 2013. Pubmed reference: 23172697. DOI: 10.1177/1098612X12467786.
2010 McIntyre, R.L., Levy, J.K., Roberts, J.F., Reep, R.L. :
Developmental uterine anomalies in cats and dogs undergoing elective ovariohysterectomy. J Am Vet Med Assoc 237:542-6, 2010. Pubmed reference: 20807131. DOI: 10.2460/javma.237.5.542.
2008 Chang, J., Jung, J.H., Yoon, J., Choi, M.C., Park, J.H., Seo, K.M., Jeong, S.M. :
Segmental aplasia of the uterine horn with ipsilateral renal agenesis in a cat. J Vet Med Sci 70:641-3, 2008. Pubmed reference: 18628611. DOI: 10.1292/jvms.70.641.
2001 Greco, D.S. :
Congenital and inherited renal disease of small animals. Vet Clin North Am Small Anim Pract 31:393-9, viii, 2001. Pubmed reference: 11265498. DOI: 10.1016/s0195-5616(01)50211-9.
1987 Lulich, J.P., Osborne, C.A., Lawler, D.F., O'Brien, T.D., Johnston, G.R., O'Leary, T.P. :
Urologic disorders of immature cats. Vet Clin North Am Small Anim Pract 17:663-96, 1987. Pubmed reference: 3300002. DOI: 10.1016/s0195-5616(87)50059-6.
1965 Robinson, G.W. :
Uterus unicornis and unilateral renal agenesis in a cat. J Am Vet Med Assoc 147:516-8, 1965. Pubmed reference: 5893299.
1949 Mack, C.O., McGlothin, J.H. :
Renal agenesis in the female cat. Anat Rec 105:445-50, illust, 1949. Pubmed reference: 15402934. DOI: 10.1002/ar.1091050306.

Edit History


  • Created by Imke Tammen2 on 13 Sep 2021
  • Changed by Imke Tammen2 on 13 Sep 2021