OMIA 002012-9615 : Glioma susceptibility in Canis lupus familiaris

In other species: pig , northern tree shrew

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 137800 (trait) , 613028 (trait) , 613029 (trait) , 607248 (trait) , 613030 (trait) , 613031 (trait) , 613032 (trait) , 613033 (trait) , 616568 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Truvé et al. (2016): "Gliomas are the most common form of malignant primary brain tumors in humans and second most common in dogs, occurring with similar frequencies in both species. Dogs are valuable spontaneous models of human complex diseases including cancers and may provide insight into disease susceptibility and oncogenesis. Several brachycephalic breeds such as Boxer, Bulldog and Boston Terrier have an elevated risk of developing glioma, but others, including Pug and Pekingese, are not at higher risk."

Mapping: "an across-breed genome-wide association study (GWAS) was performed on 39 dog glioma cases and 141 controls from 25 dog breeds, identifying a genome-wide significant locus on canine chromosome (CFA) 26 (p = 2.8 x 10−8)." (Truvé et al., 2016)

Molecular basis: Truvé et al. (2016) "identified three candidate genes that were highly associated with glioma susceptibility: CAMKK2, P2RX7 and DENR. CAMKK2 showed reduced expression in both canine and human brain tumors, and a non-synonymous variant in P2RX7, previously demonstrated to have a 50% decrease in receptor function, was also associated with disease. Thus, one or more of these genes appear to affect glioma susceptibility."

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Hicks, W.H., Bird, C.E., Pernik, M.N., Haider, A.S., Dobariya, A., Abdullah, K.G., Aoun, S.G., Bentley, R.T., Cohen-Gadol, A.A., Bachoo, R.M., Mickey, B.E., Pascual, J.M., El Ahmadieh, T.Y. :
Large animal models of glioma: Current status and future prospects. Anticancer Res 41:5343-5353, 2021. Pubmed reference: 34732404. DOI: 10.21873/anticanres.15347.
2020 Amin, S.B., Anderson, K.J., Boudreau, C.E., Martinez-Ledesma, E., Kocakavuk, E., Johnson, K.C., Barthel, F.P., Varn, F.S., Kassab, C., Ling, X., Kim, H., Barter, M., Lau, C.C., Ngan, C.Y., Chapman, M., Koehler, J.W., Long, J.P., Miller, A.D., Miller, C.R., Porter, B.F., Rissi, D.R., Mazcko, C., LeBlanc, A.K., Dickinson, P.J., Packer, R.A., Taylor, A.R., Rossmeisl, J.H., Woolard, K.D., Heimberger, A.B., Levine, J.M., Verhaak, R.G.W. :
Comparative molecular life history of spontaneous canine and human gliomas. Cancer Cell 37:243-257.e7, 2020. Pubmed reference: 32049048. DOI: 10.1016/j.ccell.2020.01.004.
LeBlanc, A.K., Mazcko, C.N. :
Improving human cancer therapy through the evaluation of pet dogs. Nat Rev Cancer 20:727-742, 2020. Pubmed reference: 32934365. DOI: 10.1038/s41568-020-0297-3.
2019 LeBlanc, A. :
A report from the NCI comparative brain tumor consortium (CBTC) glioma pathology board: A revised diagnostic classification in support of validation of the canine glioma patient as a model for humans. Vet Pathol 56:642-643, 2019. Pubmed reference: 30612539. DOI: 10.1177/0300985818819179.
2018 Hubbard, M.E., Arnold, S., Bin Zahid, A., McPheeters, M., Gerard O'Sullivan, M., Tabaran, A.F., Hunt, M.A., Pluhar, G.E. :
Naturally occurring canine glioma as a model for novel therapeutics. Cancer Invest 36:415-423, 2018. Pubmed reference: 30234401. DOI: 10.1080/07357907.2018.1514622.
2016 Herranz, C., Fernández, F., Martín-Ibáñez, R., Blasco, E., Crespo, E., De la Fuente, C., Añor, S., Rabanal, R.M., Canals, J.M., Pumarola, M. :
Spontaneously arising canine glioma as a potential model for human glioma. J Comp Pathol 154:169-79, 2016. Pubmed reference: 26804204. DOI: 10.1016/j.jcpa.2015.12.001.
MacDiarmid, J.A., Langova, V., Bailey, D., Pattison, S.T., Pattison, S.L., Christensen, N., Armstrong, L.R., Brahmbhatt, V.N., Smolarczyk, K., Harrison, M.T., Costa, M., Mugridge, N.B., Sedliarou, I., Grimes, N.A., Kiss, D.L., Stillman, B., Hann, C.L., Gallia, G.L., Graham, R.M., Brahmbhatt, H. :
Targeted doxorubicin delivery to brain tumors via minicells: Proof of principle using dogs with spontaneously occurring tumors as a model. PLoS One 11:e0151832, 2016. Pubmed reference: 27050167. DOI: 10.1371/journal.pone.0151832.
2013 Song, R.B., Vite, C.H., Bradley, C.W., Cross, J.R. :
Postmortem evaluation of 435 cases of intracranial neoplasia in dogs and relationship of neoplasm with breed, age, and body weight. J Vet Intern Med 27:1143-52, 2013. Pubmed reference: 23865437. DOI: 10.1111/jvim.12136.
2010 Dickinson, P.J., LeCouteur, R.A., Higgins, R.J., Bringas, J.R., Larson, R.F., Yamashita, Y., Krauze, M.T., Forsayeth, J., Noble, C.O., Drummond, D.C., Kirpotin, D.B., Park, J.W., Berger, M.S., Bankiewicz, K.S. :
Canine spontaneous glioma: a translational model system for convection-enhanced delivery. Neuro Oncol 12:928-40, 2010. Pubmed reference: 20488958. DOI: 10.1093/neuonc/noq046.
Reitman, Z.J., Olby, N.J., Mariani, C.L., Thomas, R., Breen, M., Bigner, D.D., McLendon, R.E., Yan, H. :
IDH1 and IDH2 hotspot mutations are not found in canine glioma. Int J Cancer 127:245-6, 2010. Pubmed reference: 19877121. DOI: 10.1002/ijc.25017.
Young, B.D., Levine, J.M., Porter, B.F., Chen-Allen, A.V., Rossmeisl, J.H., Platt, S.R., Kent, M., Fosgate, G.T., Schatzberg, S.J. :
Magnetic resonance imaging features of intracranial astrocytomas and oligodendrogliomas in dogs. Vet Radiol Ultrasound 52:132-41, 2010. Pubmed reference: 21388463. DOI: 10.1111/j.1740-8261.2010.01758.x.
2006 Snyder, J.M., Shofer, F.S., Van Winkle, T.J., Massicotte, C. :
Canine intracranial primary neoplasia: 173 cases (1986-2003). J Vet Intern Med 20:669-75, 2006. Pubmed reference: 16734106.
2003 Lipsitz, D., Higgins, R.J., Kortz, G.D., Dickinson, P.J., Bollen, A.W., Naydan, D.K., LeCouteur, R.A. :
Glioblastoma multiforme: clinical findings, magnetic resonance imaging, and pathology in five dogs. Vet Pathol 40:659-69, 2003. Pubmed reference: 14608019. DOI: 10.1354/vp.40-6-659.
2000 Rainov, N.G., Koch, S., Sena-Esteves, M., Berens, M.E. :
Characterization of a canine glioma cell line as related to established experimental brain tumor models. J Neuropathol Exp Neurol 59:607-13, 2000. Pubmed reference: 10901232.
1995 Harrington, M.L., Bagley, R.S., Moore, M.P. :
What is your neurologic diagnosis? Cerebral glioma in a dog. J Am Vet Med Assoc 206:33-5, 1995. Pubmed reference: 7744659.
1988 Whelan, H.T., Clanton, J.A., Wilson, R.E., Tulipan, N.B. :
Comparison of CT and MRI brain tumor imaging using a canine glioma model. Pediatr Neurol 4:279-83, 1988. Pubmed reference: 3242530.
1987 Whelan, H.T., Clanton, J.A., Moore, P.M., Tolner, D.J., Kessler, R.M., Whetsell, W.O. :
Magnetic resonance brain tumor imaging in canine glioma. Neurology 37:1235-9, 1987. Pubmed reference: 3601090.
1975 Hayes, H.M., Priester, W.A., Pendergrass, T.W. :
Occurrence of nervous-tissue tumors in cattle, horses, cats and dogs. Int J Cancer 15:39-47, 1975. Pubmed reference: 165149.
1974 Jones, B.R., Wood, A.K., Christie, B.A. :
Malignant glioma of the spinal cord in a dog. J Small Anim Pract 15:763-7, 1974. Pubmed reference: 4449211.
1961 Williams, J.O., Garlick, E.C., Beard, D.C. :
Glioma of the optic nerve of a dog. A case report. J Am Vet Med Assoc 138:377-8, 1961. Pubmed reference: 13785456.

Edit History


  • Created by Frank Nicholas on 19 May 2016
  • Changed by Frank Nicholas on 19 May 2016
  • Changed by Imke Tammen2 on 08 Nov 2021