OMIA 002020-9615 : Ligneous membranitis in Canis lupus familiaris

Possibly relevant human trait(s) and/or gene(s) (MIM number): 217090

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2015

Cross-species summary: Also known as Plasminogen deficiency and Ligneous conjunctivitis

Molecular basis: Ainsworth et al. (2015): an A>T SNP in an intron donor site (c.1256+2T>A)

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
PLG plasminogen Canis lupus familiaris 1 NC_006583.3 (49535260..49497229) PLG Homologene, Ensembl, NCBI gene


By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Scottish Terrier Ligneous membranitis PLG splicing c.1256+2T>A 2015 26360520


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2016 Mason, S.L., Fisher, C., Ressel, L., Bommer, N.X., Buckley, L.M., Nuttall, T. :
Presentation, clinical pathological and post-mortem findings in three related Scottish terriers with ligneous membranitis. J Small Anim Pract 57:271-276, 2016. Pubmed reference: 26840763. DOI: 10.1111/jsap.12443.
Moyer, M.A., Scott, K., Cianciolo, R.E. :
Features and outcome of a glomerulonephropathy associated with ligneous conjunctivitis in a Doberman pinscher dog. Can Vet J 57:501-6, 2016. Pubmed reference: 27152037.
2015 Ainsworth, S., Carter, S., Fisher, C., Dawson, J., Makrides, L., Nuttall, T., Mason, S.L. :
Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the plasminogen (PLG) gene. Anim Genet 46:707-10, 2015. Pubmed reference: 26360520. DOI: 10.1111/age.12339.
2012 Mason, S.L., McElroy, P., Nuttall, T. :
Genetics of ligneous membranitis in a family of Scottish terriers. J Small Anim Pract 53:668, 2012. Pubmed reference: 23898908. DOI: 10.1111/j.1748-5827.2012.01309.x.
Mason, S.L., McElroy, P., Nuttall, T. :
Ligneous membranitis in Scottish terriers. Vet Rec 171:160, 2012. Pubmed reference: 22890402. DOI: 10.1136/vr.e5382.
2009 Torres, M.D., Leiva, M., Tabar, M.D., Naranjo, C., Pastor, J., Peña, T. :
Ligneous conjunctivitis in a plasminogen-deficient dog: clinical management and 2-year follow-up. Vet Ophthalmol 12:248-53, 2009. Pubmed reference: 19604341. DOI: 10.1111/j.1463-5224.2009.00700.x.
2008 McLean, N.S., Ward, D.A., Hendrix, D.V., Donnell, R.L., Ilha, M.R. :
Ligneous conjunctivitis secondary to a congenital plasminogen deficiency in a dog. J Am Vet Med Assoc 232:715-21, 2008. Pubmed reference: 18312178. DOI: 10.2460/javma.232.5.715.
1998 Neuman, A.C., Bakke, M.H., Mackersie, C., Hellman, S., Levitt, H. :
The effect of compression ratio and release time on the categorical rating of sound quality. J Acoust Soc Am 103:2273-81, 1998. Pubmed reference: 9604341.
1996 Ramsey, D.T., Ketring, K.L., Glaze, M.B., Knight, B., Render, J.A. :
Ligneous conjunctivitis in four Doberman pinschers. J Am Anim Hosp Assoc 32:439-47, 1996. Pubmed reference: 8875361. DOI: 10.5326/15473317-32-5-439.

Edit History

  • Created by Frank Nicholas on 01 Aug 2016
  • Changed by Frank Nicholas on 01 Aug 2016