OMIA:002046-9615 : Glaucoma, primary open angle in Canis lupus familiaris

Categories: Vision / eye phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: see also entries in OMIA relating to forms of this disease for which causal variants have been identified: e.g., OMIA:001870-9615 : Glaucoma, primary open angle, ADAMTS10-related in Canis lupus familiaris; OMIA:001976-9615 : Glaucoma, primary open angle, ADAMTS17-related in Canis lupus familiaris

Markers: Kanemaki et al. (2013) reported associations between SRBD1 polymorphisms and open-angle glaucoma in Shiba-Inus and Shih-Tzus, but likely causal variants remain to be discovered.

Breeds: American Cocker Spaniel, Beagle, Shiba Inu, Shih-Tzu.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2022 Gomes, F.E., Casanova, M.I., Mouttham, L., Bannasch, D.L., Park, S., Kim, S., Young, L.J., Daley, N.L., Thomasy, S.M., Castelhano, M.G., Ledbetter, E.C., Holmberg, B., Boyd, R., Van Der Woerdt, A., McDonald, J., Hayward, J.J. :
A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels. Am J Vet Res :1-8, 2022. Pubmed reference: 36170212 . DOI: 10.2460/ajvr.22.07.0106.
2019 Park, S.A., Sledge, D., Monahan, C., Bartoe, J.T., Komáromy, A.M. :
Primary angle-closure glaucoma with goniodysgenesis in a Beagle dog. BMC Vet Res 15:75, 2019. Pubmed reference: 30832652 . DOI: 10.1186/s12917-019-1812-1.
2017 Graham, K.L., McCowan, C., White, A. :
Genetic and biochemical biomarkers in canine glaucoma. Vet Pathol 54:194-203, 2017. Pubmed reference: 27681326 . DOI: 10.1177/0300985816666611.
2013 Kanemaki, N., Tchedre, K.T., Imayasu, M., Kawarai, S., Sakaguchi, M., Yoshino, A., Itoh, N., Meguro, A., Mizuki, N. :
Dogs and humans share a common susceptibility gene SRBD1 for glaucoma risk. PLoS One 8:e74372, 2013. Pubmed reference: 24040232 . DOI: 10.1371/journal.pone.0074372.

Edit History

  • Created by Frank Nicholas on 07 Oct 2016
  • Changed by Frank Nicholas on 07 Oct 2016
  • Changed by Imke Tammen2 on 07 May 2023