OMIA:002046-9615 : Glaucoma, primary open angle in Canis lupus familiaris (dog)

Categories: Vision / eye phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: see also entries in OMIA relating to forms of this disease for which causal variants have been identified: e.g., OMIA:001870-9615 : Glaucoma, primary open angle, ADAMTS10-related in Canis lupus familiaris; OMIA:001976-9615 : Glaucoma, primary open angle, ADAMTS17-related in Canis lupus familiaris

Markers: Kanemaki et al. (2013) reported associations between SRBD1 polymorphisms and open-angle glaucoma in Shiba-Inus and Shih-Tzus, but likely causal variants remain to be discovered.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: American Cocker Spaniel (Dog) (VBO_0200038), Beagle (Dog) (VBO_0200131), Shiba Inu (Dog) (VBO_0201220), Shih Tzu (Dog) (VBO_0201223).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002046-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2022 Gomes, F.E., Casanova, M.I., Mouttham, L., Bannasch, D.L., Park, S., Kim, S., Young, L.J., Daley, N.L., Thomasy, S.M., Castelhano, M.G., Ledbetter, E.C., Holmberg, B., Boyd, R., Van Der Woerdt, A., McDonald, J., Hayward, J.J. :
A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels. Am J Vet Res :1-8, 2022. Pubmed reference: 36170212. DOI: 10.2460/ajvr.22.07.0106.
2021 Genetics Committee of the American College of Veterinary Opthalmologists :
The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition , 2021.
2019 Park, S.A., Sledge, D., Monahan, C., Bartoe, J.T., Komáromy, A.M. :
Primary angle-closure glaucoma with goniodysgenesis in a Beagle dog. BMC Vet Res 15:75, 2019. Pubmed reference: 30832652. DOI: 10.1186/s12917-019-1812-1.
2017 Graham, K.L., McCowan, C., White, A. :
Genetic and biochemical biomarkers in canine glaucoma. Vet Pathol 54:194-203, 2017. Pubmed reference: 27681326. DOI: 10.1177/0300985816666611.
2013 Kanemaki, N., Tchedre, K.T., Imayasu, M., Kawarai, S., Sakaguchi, M., Yoshino, A., Itoh, N., Meguro, A., Mizuki, N. :
Dogs and humans share a common susceptibility gene SRBD1 for glaucoma risk. PLoS One 8:e74372, 2013. Pubmed reference: 24040232. DOI: 10.1371/journal.pone.0074372.

Edit History

  • Created by Frank Nicholas on 07 Oct 2016
  • Changed by Frank Nicholas on 07 Oct 2016
  • Changed by Imke Tammen2 on 07 May 2023
  • Changed by Imke Tammen2 on 16 Jun 2023