OMIA 002074-9940 : Tail, fat in Ovis aries

Mendelian trait/disorder: no

Considered a defect: no

Key variant known: no

Mapping: Pan et al. (2019): "Our findings suggest the fixation of fat tails in domestic sheep is caused by a selective sweep near a retro-transposable hotspot at chromosome 13, the diversity of which specifically affects the expression of BMP2"


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2019 Pan, Z., Li, S., Liu, Q., Wang, Z., Zhou, Z., Di, R., An, X., Miao, B., Wang, X., Hu, W., Guo, X., Lv, S., Li, F., Ding, G., Chu, M., Li, Y. :
Rapid evolution of a retro-transposable hotspot of ovine genome underlies the alteration of BMP2 expression and development of fat tails. BMC Genomics 20:261, 2019. Pubmed reference: 30940097. DOI: 10.1186/s12864-019-5620-6.
2017 Xu, S.S., Ren, X., Yang, G.L., Xie, X.L., Zhao, Y.X., Zhang, M., Shen, Z.Q., Ren, Y.L., Gao, L., Shen, M., Kantanen, J., Li, M.H. :
Genome-wide association analysis identifies the genetic basis of fat deposition in the tails of sheep (Ovis aries). Anim Genet 48:560-569, 2017. Pubmed reference: 28677334. DOI: 10.1111/age.12572.
2016 Jafari, S., Razzagzadeh, S. :
Genetic analysis and the estimates of genetic and phenotypic correlation of growth rates, Kleiber ratios, and fat-tail dimensions with birth to yearling live body weight traits in Makuie sheep. Trop Anim Health Prod 48:667-72, 2016. Pubmed reference: 26739342. DOI: 10.1007/s11250-015-0987-0.
Liu, Z., Ji, Z., Wang, G., Chao, T., Hou, L., Wang, J. :
Genome-wide analysis reveals signatures of selection for important traits in domestic sheep from different ecoregions. BMC Genomics 17:863, 2016. Pubmed reference: 27809776. DOI: 10.1186/s12864-016-3212-2.
Yuan, Z., Liu, E., Liu, Z., Kijas, J.W., Zhu, C., Hu, S., Ma, X., Zhang, L., Du, L., Wang, H., Wei, C. :
Selection signature analysis reveals genes associated with tail type in Chinese indigenous sheep. Anim Genet :, 2016. Pubmed reference: 27807880. DOI: 10.1111/age.12477.
Yue, Y., Cheng, X., Zhao, S.G., Liu, Z., Liu, L.S., Zhou, R., Wu, J.P., Brown, M.A. :
Effects of tail docking on the expression of genes related to lipid metabolism in Lanzhou fat-tailed sheep. Genet Mol Res 15:, 2016. Pubmed reference: 27050972. DOI: 10.4238/gmr.15017323.
Zhu, C., Fan, H., Yuan, Z., Hu, S., Ma, X., Xuan, J., Wang, H., Zhang, L., Wei, C., Zhang, Q., Zhao, F., Du, L. :
Genome-wide detection of CNVs in Chinese indigenous sheep with different types of tails using ovine high-density 600K SNP arrays. Sci Rep 6:27822, 2016. Pubmed reference: 27282145. DOI: 10.1038/srep27822.
2015 Hajihosseinlo, A., Jafari, S., Ajdary, M. :
The relationship of GH and LEP gene polymorphisms with fat-tail measurements (fat-tail dimensions) in fat-tailed Makooei breed of Iranian sheep. Adv Biomed Res 4:172, 2015. Pubmed reference: 26605211. DOI: 10.4103/2277-9175.163995.
Moioli, B., Pilla, F., Ciani, E. :
Signatures of selection identify loci associated with fat tail in sheep. J Anim Sci 93:4660-9, 2015. Pubmed reference: 26523558. DOI: 10.2527/jas.2015-9389.
Xu, X.C., Li, B.B., Wei, X., Yang, Y.X., Wang, X.L., Chen, Y.L. :
Differential expression of peroxisome proliferator-activated receptor γ, fatty acid synthase, and hormone-sensitive lipase in fat-tailed and thin-tailed sheep breeds. Genet Mol Res 14:15624-33, 2015. Pubmed reference: 26634530. DOI: 10.4238/2015.December.1.14.
2013 Gan, S.Q., Zhang, W., Shen, M., Li, H., Yang, J.Q., Liang, Y.W., Gao, L., Liu, S.R., Wang, X.H. :
[Correlation analysis between polymorphism of the 59383635th locus on X chromosome and fat-tail trait in sheep]. Yi Chuan 35:1209-16, 2013. Pubmed reference: 24459894.
2012 Moradi, M.H., Nejati-Javaremi, A., Moradi-Shahrbabak, M., Dodds, K.G., McEwan, J.C. :
Genomic scan of selective sweeps in thin and fat tail sheep breeds for identifying of candidate regions associated with fat deposition. BMC Genet 13:10, 2012. Pubmed reference: 22364287. DOI: 10.1186/1471-2156-13-10.

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  • Created by Frank Nicholas on 09 Nov 2016
  • Changed by Frank Nicholas on 21 Sep 2019