OMIA 002077-9031 : Body weight in Gallus gallus |
Mendelian trait/disorder:
no
Mode of inheritance:
Multifactorial
Considered a defect:
no
Key variant known:
yes
Year key variant first reported:
2016
Molecular basis:
Jia et al. (2016): "a 54-bp insertion mutation in the upstream region of miR-15a-16 . . . resulted in lower miR-16 expression by introducing three novel splicing sites instead of the missing 5′ terminal splicing of mature miR-16. Elevating miR-16 significantly inhibited DF-1 chicken embryo cell proliferation, consistent with a role in suppression of cellular growth."
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| MIR15A | microRNA 15a | Gallus gallus | 1 | NC_006088.5 (170717838..170717756) | MIR15A | Homologene, Ensembl, NCBI gene |
Reference
| 2016 | Jia, X., Lin, H., Nie, Q., Zhang, X., Lamont, S.J. : | |
| A short insertion mutation disrupts genesis of miR-16 and causes increased body weight in domesticated chicken. Sci Rep 6:36433, 2016. Pubmed reference: 27808177. DOI: 10.1038/srep36433. |
Edit History
- Created by Frank Nicholas on 18 Nov 2016
- Changed by Frank Nicholas on 18 Nov 2016