OMIA 002123-8090 : Iridophore in Oryzias latipes

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: no

Year key variant first reported: 2017

Species-specific description: Kimura et al. (2017): "The medaka has four pigment cell types: black melanophores, yellow xanthophores, white leucophores, and silvery iridophores. The causal genes of melanophore, xanthophore, and leucophore mutants have been elucidated, but the causal gene for the iridophore mutant remains unknown. Here, we describe the iridophore mutant, guanineless (gu), which exhibits a strong reduction in visible iridophores throughout its larval to adult stages."

Molecular basis: Kimura et al. (2017): "exons 4–7 of pnp4a were deleted in the gu mutant"

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
pnp4a Oryzias latipes - no genomic information (-..-) pnp4a Ensembl

Reference


2017 Kimura, T., Takehana, Y., Naruse, K. :
pnp4a Is the Causal Gene of the Medaka Iridophore Mutant guanineless. G3 (Bethesda) 7:1357-1363, 2017. Pubmed reference: 28258112. DOI: 10.1534/g3.117.040675.

Edit History


  • Created by Frank Nicholas on 02 Sep 2017
  • Changed by Frank Nicholas on 02 Sep 2017