OMIA:002123-8090 : Iridophore reduction in Oryzias latipes (Japanese medaka)
Categories: Pigmentation phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: no
Year key variant first reported: 2017
Species-specific description: Kimura et al. (2017): "The medaka has four pigment cell types: black melanophores, yellow xanthophores, white leucophores, and silvery iridophores. The causal genes of melanophore, xanthophore, and leucophore mutants have been elucidated, but the causal gene for the iridophore mutant remains unknown. Here, we describe the iridophore mutant, guanineless (gu), which exhibits a strong reduction in visible iridophores throughout its larval to adult stages."
Molecular basis: Kimura et al. (2017): "exons 4–7 of pnp4a were deleted in the gu mutant"
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|pnp4a||Oryzias latipes||NW_004089994.1 (33648..19068)||pnp4a||Homologene, Ensembl , NCBI gene|
Cite this entry
|2017||Kimura, T., Takehana, Y., Naruse, K. :|
|pnp4a is the causal gene of the medaka iridophore mutant guanineless. G3 (Bethesda) 7:1357-1363, 2017. Pubmed reference: 28258112 . DOI: 10.1534/g3.117.040675.|
- Created by Frank Nicholas on 02 Sep 2017
- Changed by Frank Nicholas on 02 Sep 2017