OMIA 002158-9541 : Developmental retardation in Macaca fascicularis

Possibly relevant human trait(s) and/or gene(s) (MIM number): 606211

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: This is genetically-modified organism (GMO)

Molecular basis: Zhang et al. (2018) generated "a SIRT6-null cynomolgus monkey (Macaca fascicularis) model using a CRISPR-Cas9-based approach. SIRT6-deficient monkeys die hours after birth and exhibit severe prenatal developmental retardation".

Reference


2018 Zhang, W., Wan, H., Feng, G., Qu, J., Wang, J., Jing, Y., Ren, R., Liu, Z., Zhang, L., Chen, Z., Wang, S., Zhao, Y., Wang, Z., Yuan, Y., Zhou, Q., Li, W., Liu, G.H., Hu, B. :
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature 560:661-665, 2018. Pubmed reference: 30135584. DOI: 10.1038/s41586-018-0437-z.

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  • Created by Frank Nicholas on 03 Sep 2018