OMIA:002158-9541 : Developmental retardation in Macaca fascicularis (crab-eating macaque)

Categories: Mortality / aging (incl. embryonic lethal)

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 606211 (gene)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2018

Species-specific description: This is genetically-modified organism (GMO)

Molecular basis: Zhang et al. (2018) generated "a SIRT6-null cynomolgus monkey (Macaca fascicularis) model using a CRISPR-Cas9-based approach. SIRT6-deficient monkeys die hours after birth and exhibit severe prenatal developmental retardation".

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
SIRT6 sirtuin 6 Macaca fascicularis 19 NC_052273.1 (4095793..4087069) SIRT6 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002158-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2018 Zhang, W., Wan, H., Feng, G., Qu, J., Wang, J., Jing, Y., Ren, R., Liu, Z., Zhang, L., Chen, Z., Wang, S., Zhao, Y., Wang, Z., Yuan, Y., Zhou, Q., Li, W., Liu, G.H., Hu, B. :
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature 560:661-665, 2018. Pubmed reference: 30135584. DOI: 10.1038/s41586-018-0437-z.

Edit History


  • Created by Frank Nicholas on 03 Sep 2018
  • Changed by Imke Tammen2 on 10 Dec 2023