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OMIA:002158-9541 : Developmental retardation in Macaca fascicularis (crab-eating macaque)

Categories: Mortality / aging (incl. embryonic lethal)

Possibly relevant human trait(s) and/or gene(s) (MIM number): 606211 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: This is genetically-modified organism (GMO)

Molecular basis: Zhang et al. (2018) generated "a SIRT6-null cynomolgus monkey (Macaca fascicularis) model using a CRISPR-Cas9-based approach. SIRT6-deficient monkeys die hours after birth and exhibit severe prenatal developmental retardation".

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2018). OMIA:002158-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2018 Zhang, W., Wan, H., Feng, G., Qu, J., Wang, J., Jing, Y., Ren, R., Liu, Z., Zhang, L., Chen, Z., Wang, S., Zhao, Y., Wang, Z., Yuan, Y., Zhou, Q., Li, W., Liu, G.H., Hu, B. :
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature 560:661-665, 2018. Pubmed reference: 30135584. DOI: 10.1038/s41586-018-0437-z.

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  • Created by Frank Nicholas on 03 Sep 2018