OMIA:002159-9694 : Coat colour, golden in Panthera tigris
In other species: domestic cat
Categories: Pigmentation phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 605236 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: yes
Year key variant first reported: 2017
Molecular basis: Xu et al. (2017) reported that a missense variant in the CORIN gene (c.1759C >T; p.H587Y) is a likely causal variant for "golden tiger pelage", having shown that "A perfect correlation was detected between CORIN c.1759C >T and the “wideband” phenotype among unrelated individuals from wild or captive tiger populations worldwide . . . . All golden (n = 16) and snow white (n = 22) tigers were homozygous for CORIN c.1759C >T; all orange (n = 123) and white (n = 36) tigers carried at least one copy of the wild-type allele". FN is grateful to Corinne Benavides for alerting him to this discovery.
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|CORIN||corin, serine peptidase||Panthera tigris altaica||B1||NC_056663.1 (164098937..164350098)||CORIN||Homologene, Ensembl , NCBI gene|
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|1012||Golden tiger||CORIN||missense||Naturally occurring variant||c.1759C>T||p.(H587Y)||2017||28281538|
|2017||Xu, X., Dong, G.X., Schmidt-Küntzel, A., Zhang, X.L., Zhuang, Y., Fang, R., Sun, X., Hu, X.S., Zhang, T.Y., Yang, H.D., Zhang, D.L., Marker, L., Jiang, Z.F., Li, R., Luo, S.J. :|
|The genetics of tiger pelage color variations. Cell Res 27:954-957, 2017. Pubmed reference: 28281538 . DOI: 10.1038/cr.2017.32.|
- Created by Frank Nicholas on 06 Sep 2018
- Changed by Frank Nicholas on 01 Apr 2020