OMIA:002159-9694 : Coat colour, golden in Panthera tigris (tiger)

In other species: domestic cat

Categories: Pigmentation phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 605236 (gene)

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2017

Molecular basis: Xu et al. (2017) reported that a missense variant in the CORIN gene (c.1759C >T; p.H587Y) is a likely causal variant for "golden tiger pelage", having shown that "A perfect correlation was detected between CORIN c.1759C >T and the “wideband” phenotype among unrelated individuals from wild or captive tiger populations worldwide . . . . All golden (n = 16) and snow white (n = 22) tigers were homozygous for CORIN c.1759C >T; all orange (n = 123) and white (n = 36) tigers carried at least one copy of the wild-type allele". FN is grateful to Corinne Benavides for alerting him to this discovery.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
CORIN corin, serine peptidase Panthera tigris altaica B1 NC_056663.1 (164098937..164350098) CORIN Homologene, Ensembl , NCBI gene


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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.

OMIA Variant ID Breed(s) Variant Phenotype Gene Allele Type of Variant Source of Genetic Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
1012 Golden tiger CORIN missense Naturally occurring variant c.1759C>T p.(H587Y) 2017 28281538

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:002159-9694: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2017 Xu, X., Dong, G.X., Schmidt-Küntzel, A., Zhang, X.L., Zhuang, Y., Fang, R., Sun, X., Hu, X.S., Zhang, T.Y., Yang, H.D., Zhang, D.L., Marker, L., Jiang, Z.F., Li, R., Luo, S.J. :
The genetics of tiger pelage color variations. Cell Res 27:954-957, 2017. Pubmed reference: 28281538. DOI: 10.1038/cr.2017.32.

Edit History

  • Created by Frank Nicholas on 06 Sep 2018
  • Changed by Frank Nicholas on 01 Apr 2020