OMIA 002159-9694 : Coat colour, golden in Panthera tigris

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2017

Molecular basis: Xu et al. (2013) reported that a missense variant in the CORIN gene (c.1759C >T; p.H587Y) is a likely causal variant for "golden tiger pelage", having shown that "A perfect correlation was detected between CORIN c.1759C >T and the “wideband” phenotype among unrelated individuals from wild or captive tiger populations worldwide . . . . All golden (n = 16) and snow white (n = 22) tigers were homozygous for CORIN c.1759C >T; all orange (n = 123) and white (n = 36) tigers carried at least one copy of the wild-type allele". FN is grateful to Corinne Benavides for alerting him to this discovery.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
CORIN corin, serine peptidase Panthera tigris altaica - no genomic information (-..-) CORIN Homologene, Ensembl, NCBI gene

Variants

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Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Golden tiger CORIN missense c.1759C >T p.H587Y 2017 28281538

Reference


2017 Xu, X., Dong, G.X., Schmidt-Küntzel, A., Zhang, X.L., Zhuang, Y., Fang, R., Sun, X., Hu, X.S., Zhang, T.Y., Yang, H.D., Zhang, D.L., Marker, L., Jiang, Z.F., Li, R., Luo, S.J. :
The genetics of tiger pelage color variations. Cell Res 27:954-957, 2017. Pubmed reference: 28281538. DOI: 10.1038/cr.2017.32.

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  • Created by Frank Nicholas on 06 Sep 2018