OMIA 002186-9615 : Screw tail in Canis lupus familiaris

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 616331 , 601368

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2018

Molecular basis: Mansour et al. (2018) " identified a frameshift mutation in the WNT pathway gene DISHEVELLED 2 (DVL2) (Chr5: 32195043_32195044del, p = 4.37 X 10−37) as the most strongly associated [with screw tail] variant in the canine genome"

Clinical features: Mansour et al. (2018): "One group of three breeds (Bulldog, French Bulldog and Boston Terrier) is characterized by a wide head, short muzzle, widely spaced eyes, small size and abnormalities of the vertebral bones of the back and tail. These breeds are referred to as the screw tail breeds since the characteristic that is unique and easy to see in these breeds is their shortened and kinked tails."

Prevalence: Mansour et al. (2018): "This DVL2 variant was fixed in Bulldogs and French Bulldogs and had a high allele frequency (0.94) in Boston Terriers." These same authors also reported that "To confirm the association of the DVL2c.2044delC mutation with the screw tail phenotype, 667 dogs, from 49 breeds, were genotyped for the DVL2 mutation . . . . 177 dogs were from the screw tail breeds including 33 Bulldogs, 79 French Bulldogs and 65 Boston Terriers. All were homozygous for the mutant allele except 6 of the Boston Terriers (4 heterozygous, 2 wildtype). In addition, we identified dogs from several other breeds, including Pit bulls, Staffordshire Bull Terrier, Shih Tzu and mixed breeds, that are heterozygous or homozygous for the DLV2 mutation. The Pug breed has sometimes been classified with the screw tail breeds due to its curled tail; however, the tail is full length and does not have caudal vertebral malformations . . . . 29 Pugs tested were wild-type for the DVL2 mutation. Likewise, the Pug dogs do not share the high MAF with the screw tail breeds around the DVL2 mutation . . . . Three hundred and eighty five dogs from 43 other breeds were also tested and were all wild-type."

Breeds: Boston Terrier, Bulldog, French Bulldog.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
DVL2 dishevelled segment polarity protein 2 Canis lupus familiaris 5 NC_006587.3 (32201922..32194326) DVL2 Homologene, Ensembl, NCBI gene

Variants

By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Boston Terrier Bulldog French Bulldog Screw tail DVL2 deletion, small (<=20) CanFam3 5 g.32195043_32195044del c.2044delC p.Pro684LeufsX26 2018 30521570

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2018 Mansour, T.A., Lucot, K., Konopelski, S.E., Dickinson, P.J., Sturges, B.K., Vernau, K.L., Choi, S., Stern, J.A., Thomasy, S.M., Döring, S., Verstraete, F.J.M., Johnson, E.G., York, D., Rebhun, R.B., Ho, H.H., Brown, C.T., Bannasch, D.L. :
Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds. PLoS Genet 14:e1007850, 2018. Pubmed reference: 30521570. DOI: 10.1371/journal.pgen.1007850.
2014 Guevar, J., Penderis, J., Faller, K., Yeamans, C., Stalin, C., Gutierrez-Quintana, R. :
Computer-assisted radiographic calculation of spinal curvature in brachycephalic "screw-tailed" dog breeds with congenital thoracic vertebral malformations: reliability and clinical evaluation. PLoS One 9:e106957, 2014. Pubmed reference: 25198374. DOI: 10.1371/journal.pone.0106957.
Gutierrez-Quintana, R., Guevar, J., Stalin, C., Faller, K., Yeamans, C., Penderis, J. :
A proposed radiographic classification scheme for congenital thoracic vertebral malformations in brachycephalic "screw-tailed" dog breeds. Vet Radiol Ultrasound 55:585-91, 2014. Pubmed reference: 24833506. DOI: 10.1111/vru.12172.

Edit History


  • Created by Frank Nicholas on 29 Mar 2019
  • Changed by Frank Nicholas on 29 Mar 2019