OMIA:002214-9615 : Leukodystrophy, cavitating in Canis lupus familiaris |
Categories: Nervous system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Inheritance: Bjerkås (1977): "The disease is probably transmitted by autosomal recessive inheritance".
Clinical features: Bjerkås (1977): "The symptoms started at the age of 3-6 months and were dominated by visual deficiency and/or progressive locomotive abnormalities."
Pathology: Bjerkås (1977): "the most consistent lesions were found bilaterally in the region of the centrum semiovale. The optic nerves were also frequently affected, the basal ganglia and spinal cord were affected infrequently. The main lesions were confined to myelin, while axons and nerve cells were spared, particularly in the early stages of the lesions. Numerous phagocytes were observed which contained engulfed myelin and other lipid breakdown products. Ultrastructurally and histochemically the disease differs from previously described types of leucodystrophy."
Breed: Dalmatian.
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 1979 | Bjerkas, I. : |
| Hereditary leukodystrophy in Dalmatian dogs in Norway Norsk Veterinaertidsskrift 91:167-170, 1979. | |
| 1977 | Bjerkås, I. : |
| Hereditary "cavitating" leucodystrophy in Dalmation dogs. Light and electron microscopic studies. Acta Neuropathol 40:163-9, 1977. Pubmed reference: 930564 . DOI: 10.1007/bf00688706. | |
| 1974 | Bjerkas, I. : |
| Hereditary myelin defect in Dalmatian dogs in Norway Proceedings of the 12th Nordic Veterinary Congress, Reykjavik :?, 1974. |
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- Created by Frank Nicholas on 22 Oct 2019