OMIA 002219-9685 : Hypogonadotropic hypogonadism, TAC3-related in Felis catus
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|TAC3||tachykinin 3||Felis catus||B4||NC_058374.1 (83383919..83376824)||TAC3||Homologene, Ensembl, NCBI gene|
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|1132||Domestic Shorthair||Hypogonadotropic hypogonadism, TAC3-related||TAC3||missense||Naturally occurring variant||Felis_catus_9.0||B4||g.85517451C>T||c.220G>A||p.(V74M)||Hug et al. (2019): XM_003988924.5:c.220G>A; XP_003988973.1:p.(Val74Met)||2019||31615056|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Rodney, A.R., Buckley, R.M., Fulton, R.S., Fronick, C., Richmond, T., Helps, C.R., Pantke, P., Trent, D.J., Vernau, K.M., Munday, J.S., Lewin, A.C., Middleton, R., Lyons, L.A., Warren, W.C. :|
|A domestic cat whole exome sequencing resource for trait discovery. Sci Rep 11:7159, 2021. Pubmed reference: 33785770. DOI: 10.1038/s41598-021-86200-7.|
|2020||Szczerbal, I., Switonski, M. :|
|Genetic disorders of sex development in cats: An update. Anim Reprod Sci 216:106353, 2020. Pubmed reference: 32414464. DOI: 10.1016/j.anireprosci.2020.106353.|
|2019||Hug, P., Kern, P., Jagannathan, V., Leeb, T. :|
|A TAC3 missense variant in a domestic shorthair cat with testicular hypoplasia and persistent primary dentition. Genes (Basel) 10:, 2019. Pubmed reference: 31615056. DOI: 10.3390/genes10100806.|
- Created by Frank Nicholas on 23 Oct 2019
- Changed by Frank Nicholas on 23 Oct 2019
- Changed by Tosso Leeb on 24 Oct 2019
- Changed by Imke Tammen2 on 17 Sep 2021