OMIA 002248-9986 : Coat colour, dilution, generic in Oryctolagus cuniculus

In other species: horse

Mendelian trait/disorder: unknown

Considered a defect: no

Species-specific description: Chen et al. (2021): "American Chinchilla rabbit colors include light, medium, and dark shades. Light and medium Chinchilla rabbits exhibit a matte dilution relative to dark. ... Two exon skipping and a frameshift mutation within the melanophilin (MLPH) gene are associated with coat color dilution in rabbits (Lehner et al., 2013; Fontanesi et al., 2014) [see OMIA 000031-9986 : Coat colour, dilution, MLPH-related in Oryctolagus cuniculus for references]. However, these previously reported mutations associated with coat color dilution in rabbits were not identified in the Chinchilla populations investigated here (Li et al., 2020). ... We compared genome-wide DNA methylation profiles in Rex rabbit hair follicles in a Chinchilla group (Ch) and a diluted Chinchilla group (DCh) through whole-genome bisulfite sequencing (WGBS)."

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 Chen, Y., Hu, S., Liu, M., Zhao, B., Yang, N., Li, J., Chen, Q., Zhou, J., Bao, G., Wu, X. :
Analysis of Genome DNA Methylation at Inherited Coat Color Dilutions of Rex Rabbits. Front Genet 11:603528, 2020. Pubmed reference: 33552123. DOI: 10.3389/fgene.2020.603528.
Li, J., Chen, Y., Liu, M., Chen, Q., Wu, X. :
Association of melanophilin (MLPH) gene polymorphism with coat colour in Rex rabbits World Rabbit Sci 28:29, 2020. DOI: doi: 10.4995/wrs.2020.12082.

Edit History


  • Created by Imke Tammen2 on 09 Apr 2021
  • Changed by Imke Tammen2 on 09 Apr 2021