OMIA 002295-9615 : classical Ehlers-Danlos syndrome (cEDS), COL5A2-related in Canis lupus familiaris |
Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
---|---|---|---|---|---|---|
COL5A2 | collagen, type V, alpha 2 | Canis lupus familiaris | 36 | NC_051840.1 (30921527..30769002) | COL5A2 | Homologene, Ensembl, NCBI gene |
Variants
By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Type of Variant | Source of Genetic Variant | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Inferred EVA rsID | Year Published | PubMed ID(s) | Acknowledgements |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1460 | Chihuahua | Ehlers-Danlos syndrome, classic type, 2 | COL5A2 | deletion, gross (>20) | Naturally occurring variant | CanFam3.1 | 36 | g.30548697_30548723del | c.3388_3414del | p.(Lys1130_Asp1138del) | XM_005640393.3; XP_005640450.1 | 2022 | 35627319 |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2022 | Kiener, S., Chevallier, L., Jagannathan, V., Briand, A., Cochet-Faivre, N., Reyes-Gomez, E., Leeb, T. : | |
A COL5A2 in-frame deletion in a Chihuahua with Ehlers-Danlos syndrome. Genes (Basel) 13:, 2022. Pubmed reference: 35627319. DOI: 10.3390/genes13050934. | ||
2020 | Malfait, F., Castori, M., Francomano, C.A., Giunta, C., Kosho, T., Byers, P.H. : | |
The Ehlers-Danlos syndromes. Nat Rev Dis Primers 6:64, 2020. Pubmed reference: 32732924. DOI: 10.1038/s41572-020-0194-9. |
Edit History
- Created by Frank Nicholas on 30 May 2022
- Changed by Frank Nicholas on 31 May 2022
- Changed by Tosso Leeb on 02 Jun 2022