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OMIA:002311-9913 : sterile, male, NANOS2-related in Bos taurus (taurine cattle)

In other species: pig , goat

Categories: Reproductive system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 608228 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: Ciccarelli et al. (2020) "show that male mice, pigs, goats, and cattle harboring knockout alleles of the NANOS2 gene generated by CRISPR-Cas9 editing have testes that are germline ablated but otherwise structurally normal. ... Collectively, these advancements represent a major step toward realizing the enormous potential of surrogate sires as a tool for dissemination and regeneration of germplasm in all mammalian species." These are genetically-modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
NANOS2 nanos homolog 2 (Drosophila) Bos taurus 18 NC_037345.1 (53420452..53419905) NANOS2 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002311-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2022 Camargo, L.S.A., Saraiva, N.Z., Oliveira, C.S., Carmickle, A., Lemos, D.R., Siqueira, L.G.B., Denicol, A.C. :
Perspectives of gene editing for cattle farming in tropical and subtropical regions. Anim Reprod 19:e20220108, 2022. Pubmed reference: 36819485. DOI: 10.1590/1984-3143-AR2022-0108.
2020 Ciccarelli, M., Giassetti, M.I., Miao, D., Oatley, M.J., Robbins, C., Lopez-Biladeau, B., Waqas, M.S., Tibary, A., Whitelaw, B., Lillico, S., Park, C.H., Park, K.E., Telugu, B., Fan, Z., Liu, Y., Regouski, M., Polejaeva, I.A., Oatley, J.M. :
Donor-derived spermatogenesis following stem cell transplantation in sterile NANOS2 knockout males. Proc Natl Acad Sci U S A 117:24195-24204, 2020. Pubmed reference: 32929012. DOI: 10.1073/pnas.2010102117.

Edit History


  • Created by Imke Tammen2 on 18 Feb 2021
  • Changed by Imke Tammen2 on 18 Feb 2021
  • Changed by Imke Tammen2 on 18 Dec 2023