OMIA:002311-9925 : sterile, male, NANOS2-related in Capra hircus |
In other species: pig , cattle
Categories: Reproductive system phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 608228 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: no
Species-specific description: Ciccarelli et al. (2020) "show that male mice, pigs, goats, and cattle harboring knockout alleles of the NANOS2 gene generated by CRISPR-Cas9 editing have testes that are germline ablated but otherwise structurally normal. ... Collectively, these advancements represent a major step toward realizing the enormous potential of surrogate sires as a tool for dissemination and regeneration of germplasm in all mammalian species." These are genetically-modified organisms (GMO).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| NANOS2 | nanos homolog 2 (Drosophila) | Capra hircus | 18 | NC_030825.1 (54477128..54475910) | NANOS2 | Homologene, Ensembl , NCBI gene |
Reference
| 2020 | Ciccarelli, M., Giassetti, M.I., Miao, D., Oatley, M.J., Robbins, C., Lopez-Biladeau, B., Waqas, M.S., Tibary, A., Whitelaw, B., Lillico, S., Park, C.H., Park, K.E., Telugu, B., Fan, Z., Liu, Y., Regouski, M., Polejaeva, I.A., Oatley, J.M. : |
| Donor-derived spermatogenesis following stem cell transplantation in sterile <i>NANOS2</i> knockout males. Proc Natl Acad Sci U S A 117:24195-24204, 2020. Pubmed reference: 32929012 . DOI: 10.1073/pnas.2010102117. |
Edit History
- Created by Imke Tammen2 on 18 Feb 2021
- Changed by Imke Tammen2 on 18 Feb 2021