In other species: pig , taurine cattle

Categories: Reproductive system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 608228 (gene)

Mendelian trait/disorder: yes

Disease-related: yes

Key variant known: no

Species-specific description: Ciccarelli et al. (2020) "show that male mice, pigs, goats, and cattle harboring knockout alleles of the NANOS2 gene generated by CRISPR-Cas9 editing have testes that are germline ablated but otherwise structurally normal. ... Collectively, these advancements represent a major step toward realizing the enormous potential of surrogate sires as a tool for dissemination and regeneration of germplasm in all mammalian species." These are genetically-modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene: