OMIA 002323-8175 : Operculum, lack of in Sparus aurata

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Cross-species summary: Partial and/or total lack of an operculum (gill covering)

Inheritance: Negrin-Baez et al. (2015) proposed that the lack of an operculum is probably determined by genetic components.

Mapping: Negrin-Baez et al. (2016) identified two QTL for the defect in the linkage groups 9 and 10.

Bertolini et al. (2021): "two DNA pools of highly related fry, one composed of normal-looking (control) fish and the other lacking an operculum (case), were constructed and whole-genome resequencing data produced from the two were compared. The analysis revealed a 1 Mb region on chromosome 2 with higher heterozygosity in the lack of operculum DNA pool than in the control DNA pool .... This region contained 2921 SNVs, 10 of which, with predicted high impacts (three splice donor and seven stop-gained variants), were detected in novel genes that are homologous to calcium-sensing receptor-like genes ..."

Clinical features: Bertolini et al. (2021): "The operculum is a flexible bony plate that is essential for respiration by maintaining a constant water flow over the gills and that also plays an essential role in protecting the gills from pathogens and mechanical damage. Consistent with other types of deformities, total or partial lack of an operculum is observed more frequently in reared than in wild fish ...."

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Bertolini, F., Ribani, A., Capoccioni, F., Buttazzoni, L., Utzeri, V.J., Bovo, S., Schiavo, G., Caggiano, M., Rothschild, M.F., Fontanesi, L. :
A comparative whole genome sequencing analysis identified a candidate locus for lack of operculum in cultivated gilthead seabream (Sparus aurata). Anim Genet :, 2021. Pubmed reference: 33609290. DOI: 10.1111/age.13049.
2016 Negrín-Báez, D., Navarro, A., Afonso, J.M., Toro, M.A., Zamorano, M.J. :
Quantitative trait loci for a neurocranium deformity, lack of operculum, in gilthead seabream (Sparus aurata L.). Anim Genet 47:230-3, 2016. Pubmed reference: 26995565. DOI: 10.1111/age.12397.
2015 Negrín-Báez, D., Navarro, A., Lee-Montero, I., Soula, M., Afonso, J.M., Zamorano, M.J. :
Inheritance of skeletal deformities in gilthead seabream (Sparus aurata) - lack of operculum, lordosis, vertebral fusion and LSK complex. J Anim Sci 93:53-61, 2015. Pubmed reference: 25568357. DOI: 10.2527/jas.2014-7968.
2008 Castro, J., Pino‐Querido, A., Hermida, M., Chavarrías, D., Romero, R., García‐Cortés, LA., Toro, MA., Martínez, P. :
Heritability of skeleton abnormalities (lordosis, lack of operculum) in gilthead seabream (Sparus aurata) supported by microsatellite family data Aquaculture 279:18-22, 2008. DOI: https://doi.org/10.1016/j.aquaculture.2008.04.023.
2003 Beraldo, P., Pinosa, M., Tibaldi, E., Canavese, B. :
Abnormalities of the operculum in gilthead sea bream (Sparus aurata): morphological description Aquaculture 220:89-99, 2003.
1997 Koumoundouros, G., Oran, G., Divanach, P., Stefanakis, S., Kentouri, M. :
The opercular complex deformity in intensive gilthead sea bream (Sparus aurata L.) larviculture. Moment of apparition and description. Aquaculture 156:165– 177, 1997.

Edit History


  • Created by Imke Tammen2 on 09 Apr 2021
  • Changed by Imke Tammen2 on 09 Apr 2021