OMIA:002354-8128 : Male subfertility in Oreochromis niloticus (Nile tilapia)

In other species: horse , pig , taurine cattle

Categories: Reproductive system phene

Single-gene trait/disorder: unknown

Disease-related: yes

Species-specific description: Su et al. (2024) used CRISPR/Cas9 technology to create homozygous mutants of steroidogenic acute regulatory genes: star1 and star1/ star2. Gene editing of star1 and star1/star2 led to the reduction of serum corticosterone, cortisol and 11-ketotestosterone, which impaired male fertility. This study involves gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002354-8128: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2024 Su, Y., Wu, Y., Ye, M., Zhao, C., Li, L., Cai, J., Chakraborty, T., Yang, L., Wang, D., Zhou, L. :
Star1 gene mutation reveals the essentiality of 11-ketotestosterone and glucocorticoids for male fertility in Nile Tilapia (Oreochromis niloticus). Comp Biochem Physiol B Biochem Mol Biol 273:S1096-4959(24)00052-6:110985, 2024. Pubmed reference: 38729293. DOI: 10.1016/j.cbpb.2024.110985.

Edit History


  • Created by Imke Tammen2 on 06 Sep 2024
  • Changed by Imke Tammen2 on 06 Sep 2024