OMIA 002354-9913 : Male subfertility in Bos taurus

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Hiltpold et al. (2000, 20021) report several candidate genes and propose likely causal variants with an impact on male fertility in Brown Swiss cattle.

Abdollahi-Arpanahi et al.(2021) "identified a set of high-impact mutations in low-fertility bulls, including nonsense, missense, and frameshift variants. Some of these mutations may be considered as strong candidate causal variants for bull subfertility.... Genes affected by these candidate causal variants include AK9, TTLL9, TCHP, and FOXN4"

Breeds: Brown Swiss, Holstein.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Abdollahi-Arpanahi, R., Pacheco, H.A., Peñagaricano, F. :
Targeted sequencing reveals candidate causal variants for dairy bull subfertility Anim Genet. 52:509-13, 2021. Pubmed reference: 34028060. DOI: doi: 10.1111/age.13089.
Hiltpold, M., Kadri, N.K., Janett, F., Witschi, U., Schmitz-Hsu, F., Pausch, H. :
Autosomal recessive loci contribute significantly to quantitative variation of male fertility in a dairy cattle population. BMC Genomics 22:225, 2021. Pubmed reference: 33784962. DOI: 10.1186/s12864-021-07523-3.
2020 Hiltpold, M., Niu, G., Kadri, N.K., Crysnanto, D., Fang, Z.H., Spengeler, M., Schmitz-Hsu, F., Fuerst, C., Schwarzenbacher, H., Seefried, F.R., Seehusen, F., Witschi, U., Schnieke, A., Fries, R., Bollwein, H., Flisikowski, K., Pausch, H. :
Activation of cryptic splicing in bovine WDR19 is associated with reduced semen quality and male fertility. PLoS Genet 16:e1008804, 2020. Pubmed reference: 32407316. DOI: 10.1371/journal.pgen.1008804.
2019 Nani, J.P., Rezende, F.M., Peñagaricano, F. :
Predicting male fertility in dairy cattle using markers with large effect and functional annotation data. BMC Genomics 20:258, 2019. Pubmed reference: 30940077. DOI: 10.1186/s12864-019-5644-y.
2018 Nicolini, P., Amorín, R., Han, Y., Peñagaricano, F. :
Whole-genome scan reveals significant non-additive effects for sire conception rate in Holstein cattle. BMC Genet 19:14, 2018. Pubmed reference: 29486732. DOI: 10.1186/s12863-018-0600-4.

Edit History

  • Created by Imke Tammen2 on 17 Jun 2021
  • Changed by Imke Tammen2 on 17 Jun 2021
  • Changed by Imke Tammen2 on 17 Sep 2021
  • Changed by Imke Tammen2 on 22 Oct 2021
  • Changed by Imke Tammen2 on 26 Oct 2021