OMIA:002362-9925 : Fecundity, GDF9-related in Capra hircus (goat)

In other species: dog , sheep

Categories: Reproductive system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 601918 (gene) , 618014 (trait)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2016

Breeds: Bengal (Goat) (VBO_0000731), Shanbei White Cashmere, China (Goat) (VBO_0009450).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
GDF9 growth differentiation factor 9 Capra hircus 7 NC_030814.1 (66023938..66028657) GDF9 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:002362-9925: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Song, T., Liu, Y., Cuomu, R., Tan, Y., A Wang, C., De, J., Cao, X., Zeng, X. :
Polymorphisms analysis of BMP15, GDF9 and BMPR1B in Tibetan Cashmere Goat (Capra hircus). Genes (Basel) 14:1102, 2023. Pubmed reference: 37239462. DOI: 10.3390/genes14051102.
2021 Aboelhassan, D.M., Darwish, A.M., Ali, N.I., Ghaly, I.S., Farag, I.M. :
A study on mutation points of GDF9 gene and their association with prolificacy in Egyptian small ruminants. J Genet Eng Biotechnol 19:85, 2021. Pubmed reference: 34097165. DOI: 10.1186/s43141-021-00181-8.
Das, A., Shaha, M., Gupta, M.D., Dutta, A., Miazi, O.F. :
Polymorphism of fecundity genes (BMP15 and GDF9) and their association with litter size in Bangladeshi prolific Black Bengal goat. Trop Anim Health Prod 53:230, 2021. Pubmed reference: 33772358. DOI: 10.1007/s11250-021-02679-2.
2020 Bi, Y., Li, J., Wang, X., He, L., Lan, K., Qu, L., Lan, X., Song, X., Pan, C. :
Two novel rare strongly linked missense SNPs (P27R and A85G) within the GDF9 gene were significantly associated with litter size in Shaanbei White Cashmere (SBWC) goats. Front Vet Sci 7:406, 2020. Pubmed reference: 32851004. DOI: 10.3389/fvets.2020.00406.
2019 Ghoreishi, H., Fathi-Yosefabad, S., Shayegh, J., Barzegari, A. :
Identification of mutations in BMP15 and GDF9 genes associated with prolificacy of Markhoz goats. Arch Anim Breed 62:565-570, 2019. Pubmed reference: 31807668. DOI: 10.5194/aab-62-565-2019.
2018 Wang, X., Yang, Q., Wang, K., Yan, H., Pan, C., Chen, H., Liu, J., Zhu, H., Qu, L., Lan, X. :
Two strongly linked single nucleotide polymorphisms (Q320P and V397I) in GDF9 gene are associated with litter size in cashmere goats. Theriogenology 125:115-121, 2018. Pubmed reference: 30414564. DOI: 10.1016/j.theriogenology.2018.10.013.
2016 Zhao, J., Liu, S., Zhou, X., Zhang, R., Li, Y., Wang, X., Chen, Y. :
A non-synonymous mutation in GDF9 is highly associated with litter size in cashmere goats. Anim Genet 47:630-1, 2016. Pubmed reference: 27298140. DOI: 10.1111/age.12447.
2013 Pramod, R.K., Sharma, S.K., Singhi, A., Pan, S., Mitra, A. :
Differential ovarian morphometry and follicular expression of BMP15, GDF9 and BMPR1B influence the prolificacy in goat. Reprod Domest Anim 48:803-9, 2013. Pubmed reference: 23581245. DOI: 10.1111/rda.12165.

Edit History

  • Created by Imke Tammen2 on 25 Jun 2021
  • Changed by Imke Tammen2 on 25 Jun 2021
  • Changed by Imke Tammen2 on 21 May 2022