OMIA:002378-9483 : Parkinson disease, SNCA-related in Callithrix jacchus (white-tufted-ear marmoset) |
In other species: crab-eating macaque , Rhesus monkey , pig
Categories: Nervous system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 163890 (gene) , 127750 (trait) , 168601 (trait) , 605543 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Species-specific description: Kirk et al. (2003) "used a high-titer recombinant adeno-associated virus (rAAV) vector to express WT or mutant human α-synuclein in the substantia nigra of adult marmosets." (GMO)
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| SNCA | synuclein alpha | Callithrix jacchus | 3 | NC_071444.1 (103864032..103984752) | SNCA | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002378-9483: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Pan, M.T., Zhang, H., Li, X.J., Guo, X.Y. : |
| Genetically modified non-human primate models for research on neurodegenerative diseases. Zool Res 45:2095-8137(2024)02-0263-12:263-274, 2024. Pubmed reference: 38287907. DOI: 10.24272/j.issn.2095-8137.2023.197. | |
| 2023 | Khan, E., Hasan, I., Haque, M.E. : |
| Parkinson's disease: Exploring different animal model systems. Int J Mol Sci 24:9088, 2023. Pubmed reference: 37240432. DOI: 10.3390/ijms24109088. | |
| 2003 | Kirik, D., Annett, L.E., Burger, C., Muzyczka, N., Mandel, R.J., Björklund, A. : |
| Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease. Proc Natl Acad Sci U S A 100:2884-9, 2003. Pubmed reference: 12601150. DOI: 10.1073/pnas.0536383100. |
Edit History
- Created by Imke Tammen2 on 30 May 2023
- Changed by Imke Tammen2 on 30 May 2023
- Changed by Imke Tammen2 on 18 Dec 2023