OMIA:002378-9483 : Parkinson disease, SNCA-related in Callithrix jacchus (white-tufted-ear marmoset)

In other species: crab-eating macaque , Rhesus monkey , pig

Categories: Nervous system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 163890 (gene) , 127750 (trait) , 168601 (trait) , 605543 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Kirk et al. (2003) "used a high-titer recombinant adeno-associated virus (rAAV) vector to express WT or mutant human α-synuclein in the substantia nigra of adult marmosets." (GMO)

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
SNCA synuclein alpha Callithrix jacchus 3 NC_071444.1 (103864032..103984752) SNCA Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002378-9483: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Pan, M.T., Zhang, H., Li, X.J., Guo, X.Y. :
Genetically modified non-human primate models for research on neurodegenerative diseases. Zool Res 45:2095-8137(2024)02-0263-12:263-274, 2024. Pubmed reference: 38287907. DOI: 10.24272/j.issn.2095-8137.2023.197.
2023 Khan, E., Hasan, I., Haque, M.E. :
Parkinson's disease: Exploring different animal model systems. Int J Mol Sci 24:9088, 2023. Pubmed reference: 37240432. DOI: 10.3390/ijms24109088.
2003 Kirik, D., Annett, L.E., Burger, C., Muzyczka, N., Mandel, R.J., Björklund, A. :
Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease. Proc Natl Acad Sci U S A 100:2884-9, 2003. Pubmed reference: 12601150. DOI: 10.1073/pnas.0536383100.

Edit History

  • Created by Imke Tammen2 on 30 May 2023
  • Changed by Imke Tammen2 on 30 May 2023
  • Changed by Imke Tammen2 on 18 Dec 2023