OMIA 002378-9544 : Parkinson disease, SNCA-related in Macaca mulatta

In other species: pig

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 163890 (gene) , 127750 (trait) , 168601 (trait) , 605543 (trait)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: Niu et al. (2015): "We established transgenic PD [Parkinson's disease] rhesus monkeys that express mutant α-syn (A53T). Six transgenic A53T monkeys were produced via lentiviral vector expressing A53T in fertilized monkey eggs and subsequent embryo transfer to surrogates. Transgenic A53T is expressed in the monkey brain and causes age-dependent non-motor symptoms, including cognitive defects and anxiety phenotype, without detectable sleeping disorders."

This phene includes references to studies involving genetically modified organisms (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
SNCA synuclein alpha Macaca mulatta 5 NC_041758.1 (88230916..88118358) SNCA Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Yang, W., Chen, X., Li, S., Li, X.J. :
Genetically modified large animal models for investigating neurodegenerative diseases. Cell Biosci 11:218, 2021. Pubmed reference: 34933675. DOI: 10.1186/s13578-021-00729-8.
2015 Niu, Y., Guo, X., Chen, Y., Wang, C.E., Gao, J., Yang, W., Kang, Y., Si, W., Wang, H., Yang, S.H., Li, S., Ji, W., Li, X.J. :
Early Parkinson's disease symptoms in α-synuclein transgenic monkeys. Hum Mol Genet 24:2308-17, 2015. Pubmed reference: 25552648. DOI: 10.1093/hmg/ddu748.

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  • Created by Imke Tammen2 on 09 Jan 2022