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OMIA:002378-9544 : Parkinson disease, SNCA-related in Macaca mulatta (Rhesus monkey)

In other species: white-tufted-ear marmoset , crab-eating macaque , pig

Categories: Nervous system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 163890 (gene) , 127750 (trait) , 168601 (trait) , 605543 (trait)

Mendelian trait/disorder: yes

Disease-related: yes

Key variant known: no

Species-specific description: Niu et al. (2015): "We established transgenic PD [Parkinson's disease] rhesus monkeys that express mutant α-syn (A53T). Six transgenic A53T monkeys were produced via lentiviral vector expressing A53T in fertilized monkey eggs and subsequent embryo transfer to surrogates. Transgenic A53T is expressed in the monkey brain and causes age-dependent non-motor symptoms, including cognitive defects and anxiety phenotype, without detectable sleeping disorders." This phene includes references to studies involving genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
SNCA synuclein alpha Macaca mulatta 5 NC_041758.1 (88230916..88118358) SNCA Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002378-9544: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Pan, M.T., Zhang, H., Li, X.J., Guo, X.Y. :
Genetically modified non-human primate models for research on neurodegenerative diseases. Zool Res 45:2095-8137(2024)02-0263-12:263-274, 2024. Pubmed reference: 38287907. DOI: 10.24272/j.issn.2095-8137.2023.197.
2023 Dovonou, A., Bolduc, C., Soto Linan, V., Gora, C., Peralta Iii, M.R., Lévesque, M. :
Animal models of Parkinson's disease: bridging the gap between disease hallmarks and research questions. Transl Neurodegener 12:36, 2023. Pubmed reference: 37468944. DOI: 10.1186/s40035-023-00368-8.
Khan, E., Hasan, I., Haque, M.E. :
Parkinson's disease: Exploring different animal model systems. Int J Mol Sci 24:9088, 2023. Pubmed reference: 37240432. DOI: 10.3390/ijms24109088.
2021 Yang, W., Chen, X., Li, S., Li, X.J. :
Genetically modified large animal models for investigating neurodegenerative diseases. Cell Biosci 11:218, 2021. Pubmed reference: 34933675. DOI: 10.1186/s13578-021-00729-8.
2015 Niu, Y., Guo, X., Chen, Y., Wang, C.E., Gao, J., Yang, W., Kang, Y., Si, W., Wang, H., Yang, S.H., Li, S., Ji, W., Li, X.J. :
Early Parkinson's disease symptoms in α-synuclein transgenic monkeys. Hum Mol Genet 24:2308-17, 2015. Pubmed reference: 25552648. DOI: 10.1093/hmg/ddu748.

Edit History


  • Created by Imke Tammen2 on 09 Jan 2022
  • Changed by Imke Tammen2 on 18 Dec 2023