OMIA:002406-9483 : Rett syndrome, MECP2-related in Callithrix jacchus (white-tufted-ear marmoset) |
In other species: crab-eating macaque , Rhesus monkey
Categories: Nervous system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 300005 (gene) , 312750 (trait)
Single-gene trait/disorder: yes
Disease-related: yes
Key variant known: no
Molecular basis: Kishi et al. (2026) "used genome editing to generate MECP2-knockout marmosets and establish a new primate model for Rett syndrome ... "
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| MECP2 | methyl-CpG binding protein 2 | Callithrix jacchus | X | NC_133524.1 (150011296..149939070) | MECP2 | Ensembl, NCBI gene |
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Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2026). OMIA:002406-9483: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2026 | He, C.C.J., Kishi, N., Sanosaka, T., Kohyama, J., Okano, H. : |
| Single-nucleus RNA sequencing analysis of the MECP2-deficient marmoset hippocampus reveals altered maturation-associated transcriptional programs in hippocampal granule neurons. Neurosci Res 233:S0168-0102(26)00132-X:105145, 2026. Pubmed reference: 42966401. DOI: 10.1016/j.neures.2026.105145. | |
| Kishi, N., Okahara, J., Sato, K., Yoshimaru, D., Kurotaki, Y., Onishi, K., Sanosaka, T., Henry, R., Ito, T., Okuno, M, Weinstein, E.J., Crittenden, J.R., Okano, H.J., Hata, J, Kohyama, J, Sasaki, E, Shimogori, T, Okano, H : | |
| MECP2-mutant marmosets exhibit primate-specific phenotypes of Rett syndrome. bioRxiv :2026.06.26.734672, 2026. DOI: 10.64898/2026.06.26.734672. |
Edit History
- Created by Imke Tammen on 08 Nov 2026
- Changed by Imke Tammen on 08 Nov 2026