OMIA:002406-9541 : Rett syndrome, MECP2-related in Macaca fascicularis (crab-eating macaque)

In other species: Rhesus monkey

Categories: Nervous system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 300005 (gene) , 312750 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
MECP2 methyl-CpG binding protein 2 Macaca fascicularis X NC_052275.1 (148157571..148080704) MECP2 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002406-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Li, C., Xiao, Z., Li, Y., Chen, Z., Ji, X., Liu, Y., Feng, S., Zhang, Z., Zhang, K., Feng, J., Robbins, T.W., Xiong, S., Chen, Y., Xiao, X. :
Deep learning-based activity recognition and fine motor identification using 2D skeletons of cynomolgus monkeys. Zool Res 44:967-980, 2023. Pubmed reference: 37721106. DOI: 10.24272/j.issn.2095-8137.2022.449.
Veenstra-VanderWeele, J., O'Reilly, K.C., Dennis, M.Y., Uribe-Salazar, J.M., Amaral, D.G. :
Translational neuroscience approaches to understanding autism. Am J Psychiatry 180:265-276, 2023. Pubmed reference: 37002692. DOI: 10.1176/appi.ajp.20230153.
2021 Zhang, X., Lin, J.S., Spruyt, K. :
Sleep problems in Rett syndrome animal models: A systematic review. J Neurosci Res 99:529-544, 2021. Pubmed reference: 32985711. DOI: 10.1002/jnr.24730.
2020 Cai, D.C., Wang, Z., Bo, T., Yan, S., Liu, Y., Liu, Z., Zeljic, K., Chen, X., Zhan, Y., Xu, X., Du, Y., Wang, Y., Cang, J., Wang, G.Z., Zhang, J., Sun, Q., Qiu, Z., Ge, S., Ye, Z., Wang, Z. :
MECP2 duplication causes aberrant GABA pathways, circuits and behaviors in transgenic monkeys: Neural mappings to patients with autism. J Neurosci 40:3799-3814, 2020. Pubmed reference: 32269107. DOI: 10.1523/JNEUROSCI.2727-19.2020.
2019 Zhang, B., Zhou, Z., Zhou, Y., Zhang, T., Ma, Y., Niu, Y., Ji, W., Chen, Y. :
Social-valence-related increased attention in rett syndrome cynomolgus monkeys: An eye-tracking study. Autism Res 12:1585-1597, 2019. Pubmed reference: 31389199. DOI: 10.1002/aur.2189.
2017 Chen, Y., Yu, J., Niu, Y., Qin, D., Liu, H., Li, G., Hu, Y., Wang, J., Lu, Y., Kang, Y., Jiang, Y., Wu, K., Li, S., Wei, J., He, J., Wang, J., Liu, X., Luo, Y., Si, C., Bai, R., Zhang, K., Liu, J., Huang, S., Chen, Z., Wang, S., Chen, X., Bao, X., Zhang, Q., Li, F., Geng, R., Liang, A., Shen, D., Jiang, T., Hu, X., Ma, Y., Ji, W., Sun, Y.E. :
Modeling Rett Syndrome using TALEN-edited MECP2 mutant cynomolgus monkeys. Cell 169:945-955.e10, 2017. Pubmed reference: 28525759. DOI: 10.1016/j.cell.2017.04.035.

Edit History

  • Created by Imke Tammen2 on 28 Aug 2021
  • Changed by Imke Tammen2 on 28 Aug 2021
  • Changed by Imke Tammen2 on 30 Aug 2021
  • Changed by Imke Tammen2 on 16 Sep 2021
  • Changed by Imke Tammen2 on 18 Dec 2023