OMIA:002409-9615 : Vitreous degeneration in Canis lupus familiaris

Categories: Vision / eye phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: The vitreous body is the largest structure of the eye. Deterioration of collagen and hyaluronic acid in the vitreous can lead to vitreous degeneration.

Species-specific description: Krishnan et al. (2019) reported "a retrospective study of 4217 dogs from the Companion Animal Eye Registry (CAER) that underwent breed screening ophthalmic examinations between 2013 and 2016. The breeds analyzed included the Italian Greyhound, Shih Tzu, Affenpinscher, Bichon Frise, Brussels Griffon, Whippets, and Greyhound. Data collected from CAER included age, gender, number of examinations, and whether vitreous degeneration, along with cataracts, lens luxation, glaucoma and/or retinal detachment were present in either or both eyes. ... The study found that breed and age are significant drivers for developing VD. Italian Greyhounds, Brussels Griffons, and Shih Tzus have a significantly higher likelihood of VD compared to the negative control breed, the Greyhound. ... However, no association was identified between vitreous degeneration and cataracts, lens luxation, glaucoma, or retinal detachment."

Breeds: Brussels Griffon, Italian Greyhound, Shih-Tzu.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Jeon, B.J., Lee, S.J., Kim, K.L., Huh, E.A., Kim, J.Y. :
Long-term evaluation of the effects of vitreous degeneration on cataracts and retinal detachment in dogs. Vet Ophthalmol :, 2023. Pubmed reference: 36840613 . DOI: 10.1111/vop.13078.
2020 Krishnan, H., Diehl, K., Stefanovski, D., Aguirre, G.D. :
Vitreous degeneration and associated ocular abnormalities in the dog. Vet Ophthalmol 23:219-224, 2020. Pubmed reference: 31464365 . DOI: 10.1111/vop.12707.

Edit History

  • Changed by Imke Tammen2 on 28 Aug 2021
  • Created by Imke Tammen2 on 28 Aug 2021