OMIA:002409-9615 : Vitreous degeneration in Canis lupus familiaris (dog)

In other species: green monkey

Categories: Vision / eye phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: The vitreous body is the largest structure of the eye. Deterioration of collagen and hyaluronic acid in the vitreous can lead to vitreous degeneration, which may predispose to retinal detachment resulting in blindness.

Species-specific description: Krishnan et al. (2019) reported "a retrospective study of 4217 dogs from the Companion Animal Eye Registry (CAER) that underwent breed screening ophthalmic examinations between 2013 and 2016. The breeds analyzed included the Italian Greyhound, Shih Tzu, Affenpinscher, Bichon Frise, Brussels Griffon, Whippets, and Greyhound. Data collected from CAER included age, gender, number of examinations, and whether vitreous degeneration, along with cataracts, lens luxation, glaucoma and/or retinal detachment were present in either or both eyes. ... The study found that breed and age are significant drivers for developing VD. Italian Greyhounds, Brussels Griffons, and Shih Tzus have a significantly higher likelihood of VD compared to the negative control breed, the Greyhound. ... However, no association was identified between vitreous degeneration and cataracts, lens luxation, glaucoma, or retinal detachment."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Brussels Griffon (Dog) (VBO_0200241), Italian Greyhound (Dog) (VBO_0200713), Shih Tzu (Dog) (VBO_0201223).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002409-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Jeon, B.J., Lee, S.J., Kim, K.L., Huh, E.A., Kim, J.Y. :
Long-term evaluation of the effects of vitreous degeneration on cataracts and retinal detachment in dogs. Vet Ophthalmol , 2023. Pubmed reference: 36840613. DOI: 10.1111/vop.13078.
2021 Genetics Committee of the American College of Veterinary Opthalmologists :
The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition , 2021.
2020 Krishnan, H., Diehl, K., Stefanovski, D., Aguirre, G.D. :
Vitreous degeneration and associated ocular abnormalities in the dog. Vet Ophthalmol 23:219-224, 2020. Pubmed reference: 31464365. DOI: 10.1111/vop.12707.

Edit History

  • Created by Imke Tammen2 on 28 Aug 2021
  • Changed by Imke Tammen2 on 28 Aug 2021
  • Changed by Imke Tammen2 on 17 Jun 2023