OMIA:002419-9940 : Daft lamb syndrome, Type II in Ovis aries (sheep)
Categories: Nervous system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Mode of inheritance: Probably autosomal recessive
Considered a defect: yes
Species-specific name: This condition is clinically indistinguishable from daft lamb disease (OMIA 000177-9940 : Cerebellar cortical atrophy in Ovis aries), but differs by the absence of noticeable changes to the cerebellum or other parts of the CNS. In addition to typical congenital neurological clinical science, skeletal fragility and a progressive myopathy was noted.
Have human generated variants been created, e.g. through genetic engineering and gene editing
Border Leicester (Sheep) (VBO_0001347).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|1978||Bradley, R. :|
|Hereditary "daft lamb" disease of Border Leicester sheep: the ultrastructural pathology of the skeletal muscles. J Pathol 125:205-12, 1978. Pubmed reference: 722402. DOI: 10.1002/path.1711250406.|
|Bradley, R., Terlecki, S. :|
|Muscle lesions in a hereditary disease of lambs (`daft lamb disease') Neuropathology and Applied Neurobiology 4:237, 1978.|
|Terlecki, S., Richardson, C., Bradley, R., Buntain, D., Young, G.B., Pampiglione, G. :|
|A congenital disease of lambs clinically similar to 'inherited cerebellar cortical atrophy' (daft lamb disease). British Veterinary Journal 134:299-307, 1978. DOI: 10.1016/S0007-1935(17)33431-0.|
- Created by Imke Tammen2 on 10 Sep 2021
- Changed by Imke Tammen2 on 10 Sep 2021