OMIA:002419-9940 : Daft lamb syndrome, Type II in Ovis aries (sheep)

Categories: Nervous system phene

Mendelian trait/disorder: unknown

Mode of inheritance: Probably autosomal recessive

Considered a defect: yes

Species-specific name: This condition is clinically indistinguishable from daft lamb disease (OMIA 000177-9940 : Cerebellar cortical atrophy in Ovis aries), but differs by the absence of noticeable changes to the cerebellum or other parts of the CNS. In addition to typical congenital neurological clinical science, skeletal fragility and a progressive myopathy was noted.

Breed: Border Leicester (Sheep) (VBO_0001347).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:002419-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

1978 Bradley, R. :
Hereditary "daft lamb" disease of Border Leicester sheep: the ultrastructural pathology of the skeletal muscles. J Pathol 125:205-12, 1978. Pubmed reference: 722402. DOI: 10.1002/path.1711250406.
Bradley, R., Terlecki, S. :
Muscle lesions in a hereditary disease of lambs (`daft lamb disease') Neuropathology and Applied Neurobiology 4:237, 1978.
Terlecki, S., Richardson, C., Bradley, R., Buntain, D., Young, G.B., Pampiglione, G. :
A congenital disease of lambs clinically similar to 'inherited cerebellar cortical atrophy' (daft lamb disease). British Veterinary Journal 134:299-307, 1978. DOI: 10.1016/S0007-1935(17)33431-0.

Edit History

  • Created by Imke Tammen2 on 10 Sep 2021
  • Changed by Imke Tammen2 on 10 Sep 2021