OMIA:002426-10042 : Coat colour, dominant spot in Peromyscus maniculatus (North American deer mouse)
Categories: Pigmentation phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal dominant
Considered a defect: yes
Key variant known: no
Inheritance: S/S homozygotes are likely embryonic lethal
Mapping: Shang et al. (2020) "conduct a candidate gene linkage analysis for the Dominant spot trait and determined that Dominant spot is linked to a region of chromosome 20 that contains a strong candidate gene, Sox10. During the linkage analysis, we found that the spot size varied quantitively in affected Peromyscus based on genetic background."
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2020||Shang, Z., Horovitz, D.J., McKenzie, R.H., Keisler, J.L., Felder, M.R., Davis, S.W. :|
|Using genomic resources for linkage analysis in Peromyscus with an application for characterizing Dominant Spot. BMC Genomics 21:622, 2020. Pubmed reference: 32912160. DOI: 10.1186/s12864-020-06969-1.|
|2013||Vrana, P.B., Shorter, K.R., Szalai, G., Felder, M.R., Crossland, J.P., Veres, M., Allen, J.E., Wiley, C.D., Duselis, A.R., Dewey, M.J., Dawson, W.D. :|
|Peromyscus (deer mice) as developmental models. Wiley Interdiscip Rev Dev Biol 3:211-30, 2013. Pubmed reference: 24896658. DOI: 10.1002/wdev.132.|
|1936||Feldman, H.W. :|
|Piebald characters of the deer mouse. J Heredity 27:301, 1936.|
- Created by Imke Tammen2 on 16 Sep 2021
- Changed by Imke Tammen2 on 16 Sep 2021