Categories: Immune system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 109700 (gene)

Mendelian trait/disorder: yes

Disease-related: yes

Key variant known: no

Species-specific description: Sake et al. (2019) "demonstrate the feasibility of generating SLA class I knockout pigs by targeting the porcine beta-2-microglobulin gene using the CRISPR/Cas9 system. Additionally, our findings indicate for the first time that this genetic modification might have a negative impact on the viability of the animals. These issues need to be solved to unveil the real value for xenotransplantation in the future." This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene: