OMIA:002446-9615 : Alanine aminotransferase, reduced activty in Canis lupus familiaris (dog)

Categories: Homeostasis / metabolism phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 138200 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: unknown

Species-specific name: reduced ALT levels

Species-specific description: White et al. (2015): "From a cohort of dogs that had been previously genotyped on a semi-custom Illumina CanineHD array for various genome-wide association studies (GWAS) ..., we chose 353 clinically healthy, adult dogs for our analysis of clinical pathologic test results (14 hematological tests and 25 clinical chemistry tests). After correcting for age, body weight and sex, genetic associations were identified for amylase, segmented neutrophils, urea nitrogen, glucose, and mean corpuscular hemoglobin. Additionally, a strong genetic association (P = 8.1×10-13) was evident between a region of canine chromosome 13 (CFA13) and alanine aminotransferase (ALT), explaining 23% of the variation in ALT levels. This region of CFA13 encompasses the GPT gene that encodes the transferase. Dogs homozygous for the derived allele exhibit lower ALT activity, making increased ALT activity a less useful marker of hepatic injury in these individuals."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:002446-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Kim, C., Loftus, J.P., Huson, H.J. :
Low alanine aminotransferase activity gene variant in a Siberian Husky with copper-associated hepatopathy. BMC Vet Res 19:111, 2023. Pubmed reference: 37550687. DOI: 10.1186/s12917-023-03681-6.
2021 Thorsrud, J.A., Huson, H.J. :
Description of breed ancestry and genetic health traits in arctic sled dog breeds. Canine Med Genet 8:8, 2021. Pubmed reference: 34544496. DOI: 10.1186/s40575-021-00108-z.
2015 White, M.E., Hayward, J.J., Stokol, T., Boyko, A.R. :
Genetic mapping of novel loci affecting canine blood phenotypes. PLoS One 10:e0145199, 2015. Pubmed reference: 26683458. DOI: 10.1371/journal.pone.0145199.

Edit History

  • Created by Imke Tammen2 on 03 Oct 2021
  • Changed by Imke Tammen2 on 03 Oct 2021