OMIA 002446-9615 : Alanine aminotransferase, reduced activty in Canis lupus familiaris
Possibly relevant human trait(s) and/or gene(s) (MIM number): 138200 (gene) Mendelian trait/disorder: unknown Considered a defect: unknown Species-specific name: reduced ALT levels Species-specific description: White et al. (2015): "From a cohort of dogs that had been previously genotyped on a semi-custom Illumina CanineHD array for various genome-wide association studies (GWAS) ..., we chose 353 clinically healthy, adult dogs for our analysis of clinical pathologic test results (14 hematological tests and 25 clinical chemistry tests). After correcting for age, body weight and sex, genetic associations were identified for amylase, segmented neutrophils, urea nitrogen, glucose, and mean corpuscular hemoglobin. Additionally, a strong genetic association (P = 8.1×10-13) was evident between a region of canine chromosome 13 (CFA13) and alanine aminotransferase (ALT), explaining 23% of the variation in ALT levels. This region of CFA13 encompasses the GPT gene that encodes the transferase. Dogs homozygous for the derived allele exhibit lower ALT activity, making increased ALT activity a less useful marker of hepatic injury in these individuals."
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Thorsrud, J.A., Huson, H.J. :|
|Description of breed ancestry and genetic health traits in arctic sled dog breeds. Canine Med Genet 8:8, 2021. Pubmed reference: 34544496. DOI: 10.1186/s40575-021-00108-z.|
|2015||White, M.E., Hayward, J.J., Stokol, T., Boyko, A.R. :|
|Genetic mapping of novel loci affecting canine blood phenotypes. PLoS One 10:e0145199, 2015. Pubmed reference: 26683458. DOI: 10.1371/journal.pone.0145199.|
- Created by Imke Tammen2 on 03 Oct 2021
- Changed by Imke Tammen2 on 03 Oct 2021