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OMIA:002488-9615 : Parkinson disease, PARK7-related in Canis lupus familiaris (dog)

In other species: Rhesus monkey , pig

Categories: Nervous system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 602533 (gene) , 606324 (trait)

Mendelian trait/disorder: yes

Disease-related: yes

Key variant known: no

Cross-species summary: PARK7 is also known as DJ-1

Species-specific description: Kim et al. (2022) "generated two genome-edited dogs. Both genome-edited dogs had insertion-deletion mutations at the target [DJ-1 - also known as PARK7] locus, and DJ-1 expression was either downregulated or completely repressed." This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
PARK7 parkinson protein 7 Canis lupus familiaris 5 NC_051809.1 (61791984..61808701) PARK7 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002488-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2022 Kim, D.E., Lee, J.H., Ji, K.B., Park, K.S., Kil, T.Y., Koo, O., Kim, M.K. :
Generation of genome-edited dogs by somatic cell nuclear transfer. BMC Biotechnol 22:19, 2022. Pubmed reference: 35831828. DOI: 10.1186/s12896-022-00749-3.

Edit History


  • Created by Imke Tammen2 on 13 Jan 2023
  • Changed by Imke Tammen2 on 13 Jan 2023
  • Changed by Imke Tammen2 on 16 Oct 2023
  • Changed by Imke Tammen2 on 18 Dec 2023