OMIA 002488-9823 : Parkinson disease, PARK7-related in Sus scrofa

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 602533 (gene) , 606324 (trait)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2014

Species-specific description: Yao et al. (2014) "successfully used single-strand oligodeoxynucleotides to introduce a short sequence into the DJ-1 locus [also called PARK7]. Mixed DJ-1 mutant colonies were used as donor cells for somatic cell nuclear transfer (SCNT), and three female piglets were obtained (two were bi-allelically mutated, and one was mono-allelically mutated). Western blot analysis showed that the expression of the DJ-1 protein was disrupted in KO piglets. These results imply that a combination of TALENs technology with SCNT can efficiently generate bi-allelic KO pigs without the integration of exogenous DNA."

This phene includes references to studies involving genetically modified organisms (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
PARK7 parkinson protein 7 Sus scrofa 6 NC_010448.4 (68629327..68645147) PARK7 Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Tanihara, F., Hirata, M., Otoi, T. :
Current status of the application of gene editing in pigs. J Reprod Dev 67:177-187, 2021. Pubmed reference: 33840678. DOI: 10.1262/jrd.2021-025.
2014 Yao, J., Huang, J., Hai, T., Wang, X., Qin, G., Zhang, H., Wu, R., Cao, C., Xi, J.J., Yuan, Z., Zhao, J. :
Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs. Sci Rep 4:6926, 2014. Pubmed reference: 25370805. DOI: 10.1038/srep06926.

Edit History


  • Created by Imke Tammen2 on 26 Dec 2021
  • Changed by Imke Tammen2 on 26 Dec 2021