OMIA:002488-9615 : Parkinson disease, PARK7-related in Canis lupus familiaris (dog)
Categories: Nervous system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: no
Cross-species summary: PARK7 is also known as DJ-1
Species-specific description: Kim et al. (2022) "generated two genome-edited dogs. Both genome-edited dogs had insertion-deletion mutations at the target [DJ-1 - also known as PARK7] locus, and DJ-1 expression was either downregulated or completely repressed."
This study involves genetically modified organisms (GMO).
Have human generated variants been created, e.g. through genetic engineering and gene editing
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|PARK7||parkinson protein 7||Canis lupus familiaris||5||NC_051809.1 (61791984..61808701)||PARK7||Homologene, Ensembl , NCBI gene|
Cite this entry
|2022||Kim, D.E., Lee, J.H., Ji, K.B., Park, K.S., Kil, T.Y., Koo, O., Kim, M.K. :|
|Generation of genome-edited dogs by somatic cell nuclear transfer. BMC Biotechnol 22:19, 2022. Pubmed reference: 35831828. DOI: 10.1186/s12896-022-00749-3.|
- Created by Imke Tammen2 on 13 Jan 2023
- Changed by Imke Tammen2 on 13 Jan 2023
- Changed by Imke Tammen2 on 16 Oct 2023