OMIA:002489-9823 : Spermatogenic arrest, DAZL-related in Sus scrofa (pig) |
Categories: Reproductive system phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 601486 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: no
Species-specific description: Tan et al. (2013): "Edited fibroblasts were used to generate pigs with knockout alleles in the DAZL and APC genes to model infertility and colon cancer."
This phene includes references to studies involving genetically modified organisms (GMO).
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| DAZL | deleted in azoospermia-like | Sus scrofa | - | no genomic information (-..-) | DAZL | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:002489-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2023 | Lara, N.L.M., Goldsmith, T., Rodriguez-Villamil, P., Ongaratto, F., Solin, S., Webster, D., Ganbaatar, U., Hodgson, S., Corbière, S.M.A.S., Bondareva, A., Carlson, D.F., Dobrinski, I. : |
| DAZL knockout pigs as recipients for spermatogonial stem cell transplantation. Cells 12, 2023. Pubmed reference: 37947660. DOI: 10.3390/cells12212582. | |
| 2021 | Tanihara, F., Hirata, M., Otoi, T. : |
| Current status of the application of gene editing in pigs. J Reprod Dev 67:177-187, 2021. Pubmed reference: 33840678. DOI: 10.1262/jrd.2021-025. | |
| 2013 | Tan, W., Carlson, D.F., Lancto, C.A., Garbe, J.R., Webster, D.A., Hackett, P.B., Fahrenkrug, S.C. : |
| Efficient nonmeiotic allele introgression in livestock using custom endonucleases. Proc Natl Acad Sci U S A 110:16526-31, 2013. Pubmed reference: 24014591. DOI: 10.1073/pnas.1310478110. |
Edit History
- Created by Imke Tammen2 on 26 Dec 2021
- Changed by Imke Tammen2 on 26 Dec 2021