OMIA:002490-9986 : Hyperlipidaemia/atherosclerosis, APOC3-related in Oryctolagus cuniculus (rabbit) |
Categories: Cardiovascular system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 107720 (gene) , 614028 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: no
Species-specific description: Zha et al. (2021): "High levels of apolipoprotein C3 (APOC3) can lead to hypertriglyceridemia, which increases the risk of cardiovascular disease. ... An APOC3-KO rabbit model was constructed using CRISPR/Cas9 gene editing technology. APOC3 deficiency alleviated cholesterol-induced hyperlipidemia and reduced atherosclerotic plaque formation."
This phene includes references to studies involving genetically modified organisms (GMO).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| APOC3 | apolipoprotein C-III | Oryctolagus cuniculus | 1 | NC_067374.1 (113568671..113567203) | APOC3 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:002490-9986: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2021 | Zha, Y., Lu, Y., Zhang, T., Yan, K., Zhuang, W., Liang, J., Cheng, Y., Wang, Y. : |
| CRISPR/Cas9-mediated knockout of APOC3 stabilizes plasma lipids and inhibits atherosclerosis in rabbits. Lipids Health Dis 20:180, 2021. Pubmed reference: 34922545 . DOI: 10.1186/s12944-021-01605-7. |
Edit History
- Created by Imke Tammen2 on 09 Jan 2022
- Changed by Imke Tammen2 on 09 Jan 2022