OMIA:002490-9986 : Hyperlipidaemia/atherosclerosis, APOC3-related in Oryctolagus cuniculus (rabbit)
Categories: Cardiovascular system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: no
Species-specific description: Zha et al. (2021): "High levels of apolipoprotein C3 (APOC3) can lead to hypertriglyceridemia, which increases the risk of cardiovascular disease. ... An APOC3-KO rabbit model was constructed using CRISPR/Cas9 gene editing technology. APOC3 deficiency alleviated cholesterol-induced hyperlipidemia and reduced atherosclerotic plaque formation."
This phene includes references to studies involving genetically modified organisms (GMO).
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|APOC3||apolipoprotein C-III||Oryctolagus cuniculus||1||NC_067374.1 (113568671..113567203)||APOC3||Homologene, Ensembl , NCBI gene|
Cite this entry
|2021||Zha, Y., Lu, Y., Zhang, T., Yan, K., Zhuang, W., Liang, J., Cheng, Y., Wang, Y. :|
|CRISPR/Cas9-mediated knockout of APOC3 stabilizes plasma lipids and inhibits atherosclerosis in rabbits. Lipids Health Dis 20:180, 2021. Pubmed reference: 34922545 . DOI: 10.1186/s12944-021-01605-7.|
- Created by Imke Tammen2 on 09 Jan 2022
- Changed by Imke Tammen2 on 09 Jan 2022