OMIA 002490-9986 : Hyperlipidaemia/atherosclerosis, APOC3-related in Oryctolagus cuniculus

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 107720 (gene) , 614028 (trait)

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: no

Species-specific description: Zha et al. (2021): "High levels of apolipoprotein C3 (APOC3) can lead to hypertriglyceridemia, which increases the risk of cardiovascular disease. ... An APOC3-KO rabbit model was constructed using CRISPR/Cas9 gene editing technology. APOC3 deficiency alleviated cholesterol-induced hyperlipidemia and reduced atherosclerotic plaque formation."

This phene includes references to studies involving genetically modified organisms (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
APOC3 apolipoprotein C-III Oryctolagus cuniculus 1 NC_013669.1 (99602136..99600661) APOC3 Homologene, Ensembl, NCBI gene

Reference


2021 Zha, Y., Lu, Y., Zhang, T., Yan, K., Zhuang, W., Liang, J., Cheng, Y., Wang, Y. :
CRISPR/Cas9-mediated knockout of APOC3 stabilizes plasma lipids and inhibits atherosclerosis in rabbits. Lipids Health Dis 20:180, 2021. Pubmed reference: 34922545. DOI: 10.1186/s12944-021-01605-7.

Edit History


  • Created by Imke Tammen2 on 09 Jan 2022
  • Changed by Imke Tammen2 on 09 Jan 2022