OMIA 002490-9986 : Hyperlipidaemia/atherosclerosis, APOC3-related in Oryctolagus cuniculus |
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers):
107720 (gene)
,
614028 (trait)
Mendelian trait/disorder:
yes
Considered a defect:
no
Key variant known:
no
Species-specific description:
Zha et al. (2021): "High levels of apolipoprotein C3 (APOC3) can lead to hypertriglyceridemia, which increases the risk of cardiovascular disease. ... An APOC3-KO rabbit model was constructed using CRISPR/Cas9 gene editing technology. APOC3 deficiency alleviated cholesterol-induced hyperlipidemia and reduced atherosclerotic plaque formation."
This phene includes references to studies involving genetically modified organisms (GMO).
Associated gene:| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| APOC3 | apolipoprotein C-III | Oryctolagus cuniculus | 1 | NC_013669.1 (99602136..99600661) | APOC3 | Homologene, Ensembl, NCBI gene |
Reference
| 2021 | Zha, Y., Lu, Y., Zhang, T., Yan, K., Zhuang, W., Liang, J., Cheng, Y., Wang, Y. : | |
| CRISPR/Cas9-mediated knockout of APOC3 stabilizes plasma lipids and inhibits atherosclerosis in rabbits. Lipids Health Dis 20:180, 2021. Pubmed reference: 34922545. DOI: 10.1186/s12944-021-01605-7. |
Edit History
- Created by Imke Tammen2 on 09 Jan 2022
- Changed by Imke Tammen2 on 09 Jan 2022