OMIA 002496-9823 : Intramuscular fat, PPARG-related in Sus scrofa |
Possibly relevant human trait(s) and/or gene(s) (MIM number):
601487 (gene)
Mendelian trait/disorder:
yes
Considered a defect:
no
Key variant known:
no
Species-specific description:
Gu et al. (2021) "generated muscle-specific overexpression of PPARγ [PPARG] in two pig models by random insertion and CRISPR/Cas9 transgenic cloning procedures. The content of intramuscular fat was significantly increased in PPARγ pigs while [the genome editing] had no changes on lean meat ratio."
This phene includes references to studies involving genome edited or genetically modified organisms (GMO).
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2022 | Tu, C.F., Chuang, C.K., Yang, T.S. : | |
The application of new breeding technology based on gene editing in pig industry. Anim Biosci :, 2022. Pubmed reference: 34991204. DOI: 10.5713/ab.21.0390. | ||
2021 | Gu, H., Zhou, Y., Yang, J., Li, J., Peng, Y., Zhang, X., Miao, Y., Jiang, W., Bu, G., Hou, L., Li, T., Zhang, L., Xia, X., Ma, Z., Xiong, Y., Zuo, B. : | |
Targeted overexpression of PPARγ in skeletal muscle by random insertion and CRISPR/Cas9 transgenic pig cloning enhances oxidative fiber formation and intramuscular fat deposition. FASEB J 35:e21308, 2021. Pubmed reference: 33481304. DOI: 10.1096/fj.202001812RR. |
Edit History
- Created by Imke Tammen2 on 11 Jan 2022