OMIA:002496-9823 : Intramuscular fat, PPARG-related in Sus scrofa (pig)
Categories: Adipose tissue phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 601487 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: no
Species-specific description: Gu et al. (2021) "generated muscle-specific overexpression of PPARγ [PPARG] in two pig models by random insertion and CRISPR/Cas9 transgenic cloning procedures. The content of intramuscular fat was significantly increased in PPARγ pigs while [the genome editing] had no changes on lean meat ratio."
This phene includes references to studies involving genome edited or genetically modified organisms (GMO).
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2022||Tu, C.F., Chuang, C.K., Yang, T.S. :|
|The application of new breeding technology based on gene editing in pig industry - A review. Anim Biosci 35:791-803, 2022. Pubmed reference: 34991204. DOI: 10.5713/ab.21.0390.|
|2021||Gu, H., Zhou, Y., Yang, J., Li, J., Peng, Y., Zhang, X., Miao, Y., Jiang, W., Bu, G., Hou, L., Li, T., Zhang, L., Xia, X., Ma, Z., Xiong, Y., Zuo, B. :|
|Targeted overexpression of PPARγ in skeletal muscle by random insertion and CRISPR/Cas9 transgenic pig cloning enhances oxidative fiber formation and intramuscular fat deposition. FASEB J 35:e21308, 2021. Pubmed reference: 33481304. DOI: 10.1096/fj.202001812RR.|
- Created by Imke Tammen2 on 11 Jan 2022