OMIA:002497-9823 : Resistance/susceptibility to African swine fever virus (ASFV) in Sus scrofa (pig)

In other species: Common warthog

Categories: Immune system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 164014 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Considered a defect: yes

Key variant known: no

Species-specific description: This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:002497-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Feng, W., Zhou, L., Zhao, P., Du, H., Diao, C., Zhang, Y., Liu, Z., Jin, W., Yu, J., Han, J., Okoth, E., Mrode, R., Liu, J.F. :
Comparative genomic analysis of warthog and Sus scrofa identifies adaptive genes associated with African swine fever. Biology (Basel) 12, 2023. Pubmed reference: 37508430. DOI: 10.3390/biology12071001.
2022 Tu, C.F., Chuang, C.K., Yang, T.S. :
The application of new breeding technology based on gene editing in pig industry - A review. Anim Biosci 35:791-803, 2022. Pubmed reference: 34991204. DOI: 10.5713/ab.21.0390.
2021 Penrith, M.L., Bastos, A., Chenais, E. :
With or without a Vaccine-A Review of Complementary and Alternative Approaches to Managing African Swine Fever in Resource-Constrained Smallholder Settings. Vaccines (Basel) 9, 2021. Pubmed reference: 33540948. DOI: 10.3390/vaccines9020116.
2020 McCleary, S., Strong, R., McCarthy, R.R., Edwards, J.C., Howes, E.L., Stevens, L.M., Sánchez-Cordón, P.J., Núñez, A., Watson, S., Mileham, A.J., Lillico, S.G., Tait-Burkard, C., Proudfoot, C., Ballantyne, M., Whitelaw, C.B.A., Steinbach, F., Crooke, H.R. :
Substitution of warthog NF-κB motifs into RELA of domestic pigs is not sufficient to confer resilience to African swine fever virus. Sci Rep 10:8951, 2020. Pubmed reference: 32488046. DOI: 10.1038/s41598-020-65808-1.
2019 Zhao, J., Lai, L., Ji, W., Zhou, Q. :
Genome editing in large animals: current status and future prospects. Natl Sci Rev 6:402-420, 2019. Pubmed reference: 34691891. DOI: 10.1093/nsr/nwz013.
2017 Popescu, L., Gaudreault, N.N., Whitworth, K.M., Murgia, M.V., Nietfeld, J.C., Mileham, A., Samuel, M., Wells, K.D., Prather, R.S., Rowland, R.R.R. :
Genetically edited pigs lacking CD163 show no resistance following infection with the African swine fever virus isolate, Georgia 2007/1. Virology 501:102-106, 2017. Pubmed reference: 27898335. DOI: 10.1016/j.virol.2016.11.012.
2016 Lillico, S.G., Proudfoot, C., King, T.J., Tan, W., Zhang, L., Mardjuki, R., Paschon, D.E., Rebar, E.J., Urnov, F.D., Mileham, A.J., McLaren, D.G., Whitelaw, C.B. :
Mammalian interspecies substitution of immune modulatory alleles by genome editing. Sci Rep 6:21645, 2016. Pubmed reference: 26898342. DOI: 10.1038/srep21645.
2011 Palgrave, C.J., Gilmour, L., Lowden, C.S., Lillico, S.G., Mellencamp, M.A., Whitelaw, C.B. :
Species-specific variation in RELA underlies differences in NF-κB activity: a potential role in African swine fever pathogenesis. J Virol 85:6008-14, 2011. Pubmed reference: 21450812. DOI: 10.1128/JVI.00331-11.
2003 Sánchez-Torres, C., Gómez-Puertas, P., Gómez-del-Moral, M., Alonso, F., Escribano, J.M., Ezquerra, A., Domínguez, J. :
Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection. Arch Virol 148:2307-23, 2003. Pubmed reference: 14648288. DOI: 10.1007/s00705-003-0188-4.

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  • Created by Imke Tammen2 on 11 Jan 2022