OMIA:002497-9823 : Resistance/susceptibility to African swine fever virus (ASFV) in Sus scrofa (pig)

In other species: Common warthog

Categories: Immune system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 164014 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Considered a defect: yes

Key variant known: no

Species-specific description: This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002497-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Banabazi, M.H., Freimanis, G., Goatley, L.C., Netherton, C.L., de Koning, D.J. :
The transcriptomic insight into the differential susceptibility of African Swine Fever in inbred pigs. Sci Rep 14:5944, 2024. Pubmed reference: 38467747. DOI: 10.1038/s41598-024-56569-2.
2023 Feng, W., Zhou, L., Zhao, P., Du, H., Diao, C., Zhang, Y., Liu, Z., Jin, W., Yu, J., Han, J., Okoth, E., Mrode, R., Liu, J.F. :
Comparative genomic analysis of warthog and Sus scrofa identifies adaptive genes associated with African swine fever. Biology (Basel) 12:1001, 2023. Pubmed reference: 37508430. DOI: 10.3390/biology12071001.
2022 Tu, C.F., Chuang, C.K., Yang, T.S. :
The application of new breeding technology based on gene editing in pig industry - A review. Anim Biosci 35:791-803, 2022. Pubmed reference: 34991204. DOI: 10.5713/ab.21.0390.
2021 Penrith, M.L., Bastos, A., Chenais, E. :
With or without a Vaccine-A review of complementary and alternative approaches to managing African swine fever in resource-constrained smallholder settings. Vaccines (Basel) 9:116, 2021. Pubmed reference: 33540948. DOI: 10.3390/vaccines9020116.
2020 McCleary, S., Strong, R., McCarthy, R.R., Edwards, J.C., Howes, E.L., Stevens, L.M., Sánchez-Cordón, P.J., Núñez, A., Watson, S., Mileham, A.J., Lillico, S.G., Tait-Burkard, C., Proudfoot, C., Ballantyne, M., Whitelaw, C.B.A., Steinbach, F., Crooke, H.R. :
Substitution of warthog NF-κB motifs into RELA of domestic pigs is not sufficient to confer resilience to African swine fever virus. Sci Rep 10:8951, 2020. Pubmed reference: 32488046. DOI: 10.1038/s41598-020-65808-1.
2019 Zhao, J., Lai, L., Ji, W., Zhou, Q. :
Genome editing in large animals: current status and future prospects. Natl Sci Rev 6:402-420, 2019. Pubmed reference: 34691891. DOI: 10.1093/nsr/nwz013.
2017 Popescu, L., Gaudreault, N.N., Whitworth, K.M., Murgia, M.V., Nietfeld, J.C., Mileham, A., Samuel, M., Wells, K.D., Prather, R.S., Rowland, R.R.R. :
Genetically edited pigs lacking CD163 show no resistance following infection with the African swine fever virus isolate, Georgia 2007/1. Virology 501:102-106, 2017. Pubmed reference: 27898335. DOI: 10.1016/j.virol.2016.11.012.
2016 Lillico, S.G., Proudfoot, C., King, T.J., Tan, W., Zhang, L., Mardjuki, R., Paschon, D.E., Rebar, E.J., Urnov, F.D., Mileham, A.J., McLaren, D.G., Whitelaw, C.B. :
Mammalian interspecies substitution of immune modulatory alleles by genome editing. Sci Rep 6:21645, 2016. Pubmed reference: 26898342. DOI: 10.1038/srep21645.
2011 Palgrave, C.J., Gilmour, L., Lowden, C.S., Lillico, S.G., Mellencamp, M.A., Whitelaw, C.B. :
Species-specific variation in RELA underlies differences in NF-κB activity: a potential role in African swine fever pathogenesis. J Virol 85:6008-14, 2011. Pubmed reference: 21450812. DOI: 10.1128/JVI.00331-11.
2003 Sánchez-Torres, C., Gómez-Puertas, P., Gómez-del-Moral, M., Alonso, F., Escribano, J.M., Ezquerra, A., Domínguez, J. :
Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection. Arch Virol 148:2307-23, 2003. Pubmed reference: 14648288. DOI: 10.1007/s00705-003-0188-4.

Edit History


  • Created by Imke Tammen2 on 11 Jan 2022
  • Changed by Imke Tammen2 on 18 Dec 2023