OMIA 002514-9913 : Haplotypes with homozygous deficiency OH2-OH6 in Bos taurus |
The mapping information for the haplotypes with homozygous deficiency identified in the Original Braunvieh population are described below. Haplotypes for which a likely causal variant has been proposed (OH2 and OH4) have additional OMIA entries which contain the variant information.
Mapping: Häfliger et al. (2021) “The OB dataset included 10,085 genotyped animals, … [with] 3287 trios (trio: sire, dam, and offspring) … . … we detected “five significant novel haplotypes [with homozygous deficiency (OH2-6)]Mapping positions for each haplotype are based on the ARS-UCS1.2 reference genome:
Haplotype OH2 Chr2:1005580-1614673 -Proposed associated gene TUBGCP5 – see OMIA 002515-9913
Haplotype OH3 Chr11:10406494-104418358 -Proposed associated gene MYMK
Haplotype OH4 Chr19:14336760-15222429 -Proposed associated gene LIG3 – see OMIA002516-9913
Haplotype OH5 Chr21:5195518-6367707 -Proposed associated gene LYSMD4
Haplotype OH6 Chr25:9596610-10624288 -Proposed associated gene USP7
Breed: Braunvieh.Reference
2021 | Häfliger, I.M., Seefried, F.R., Spengeler, M., Drögemüller, C. : | |
Mining massive genomic data of two Swiss Braunvieh cattle populations reveals six novel candidate variants that impair reproductive success. Genet Sel Evol 53:95, 2021. Pubmed reference: 34915862. DOI: 10.1186/s12711-021-00686-3. |
Edit History
- Created by Imke Tammen2 on 14 Jan 2022
- Changed by Imke Tammen2 on 14 Jan 2022