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OMIA:002570-38626 : Chlamydia infection, susceptibility to in Phascolarctos cinereus (koala)

Categories: Immune system phene

Single-gene trait/disorder: no

Mode of inheritance: Multifactorial

Disease-related: yes

Key variant known: no

Inheritance: Cristescu et al. (2022) "investigated the genetic basis of variation in susceptibility to chlamydia ... . We combined data from veterinary examinations, chlamydia testing, genetic sampling and movement monitoring. Out of our sample of 342 wild koalas, 60 were found to have chlamydia. Using genotype information on 5007 SNPs to investigate the role of genetic variation in determining disease status, we found no evidence of inbreeding depression, but a heritability of 0.11 (95%CI = 0.06 - 0.23) for the probability that koalas had chlamydia."

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:002570-38626: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2025 Petrohilos, C., Peel, E., Silver, L.W., Belov, K., Hogg, C.J. :
AMPed up immunity: 418 whole genomes reveal intraspecific diversity of koala antimicrobial peptides. Immunogenetics 77:11, 2025. Pubmed reference: 39779522. DOI: 10.1007/s00251-024-01368-2.
2024 Cui, J., Batley, K.C., Silver, L.W., McLennan, E.A., Hogg, C.J., Belov, K. :
Spatial variation in toll-like receptor diversity in koala populations across their geographic distribution. Immunogenetics 77:5, 2024. Pubmed reference: 39614880. DOI: 10.1007/s00251-024-01365-5.
Kidd, A., Casteriano, A., Krockenberger, M.B., Higgins, D.P., Wright, B.R. :
Koala MHCII association with chlamydia infertility remains equivocal: a need for new research approaches. Sci Rep 14:31074, 2024. Pubmed reference: 39730801. DOI: 10.1038/s41598-024-82217-w.
Phillips, S., Madden, D., Gillett, A., Quigley, B.L., Jelocnik, M., Bommana, S., O'Meally, D., Timms, P., Polkinghorne, A. :
Koala ocular disease grades are defined by chlamydial load changes and increases in Th2 immune responses. Front Cell Infect Microbiol 14:1447119, 2024. Pubmed reference: 39600869. DOI: 10.3389/fcimb.2024.1447119.
2023 Charalambous, R., Narayan, E. :
Correction: A 29-year retrospective analysis of koala rescues in New South Wales, Australia. PLoS One 18:e0292911, 2023. Pubmed reference: 37815993. DOI: 10.1371/journal.pone.0292911.
2022 Cristescu, R.H., Strickland, K., Schultz, A.J., Kruuk, L.E.B., de Villiers, D., Frère, C.H. :
Susceptibility to a sexually transmitted disease in a wild koala population shows heritable genetic variance but no inbreeding depression. Mol Ecol 31:5455-5467, 2022. Pubmed reference: 36043238. DOI: 10.1111/mec.16676.

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  • Created by Imke Tammen2 on 11 Sep 2022