OMIA:002599-9615 : Iris sphincter dysplasia in Canis lupus familiaris (dog)

Categories: Vision / eye phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific symbol: ISD

Species-specific description: Genetics Committee of the American College of Veterinary Opthalmologists 2015): "Defective development of the iris, or part of the iris, resulting in an immature state. ISD [Iris sphincter dysplasia] is the result of poorly developed iris sphincter muscles. The pupils of dogs with ISD do not properly contract in bright light. Dogs usually are uncomfortable and often squint in sunlight. The disorder exposes the interior of the eye to ultraviolet light that may potentially cause serious vision problems, such as cataracts or retinal damage, as dogs age."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breed: Dalmatian (Dog) (VBO_0200427).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002599-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 Genetics Committee of the American College of Veterinary Opthalmologists :
The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition , 2021.
2015 Genetics Committee of the American College of Veterinary Ophthalmologists :
Ocular Disorders Presumed to be Inherited in Purebred Dogs (“The Blue Book”), 8th edition :354-356, 2015.

Edit History

  • Created by Imke Tammen2 on 17 Nov 2022
  • Changed by Imke Tammen2 on 17 Jun 2023